The Unexplored Diversity of Pleolipoviruses: The Surprising Case of Two Viruses with Identical Major Structural Modules

Genes
Nina S AtanasovaHanna M Oksanen

Abstract

Extremely halophilicArchaeaare the only known hosts for pleolipoviruses which are pleomorphic non-lytic viruses resembling cellular membrane vesicles. Recently, pleolipoviruses have been acknowledged by the International Committee on Taxonomy of Viruses (ICTV) as the first virus family that contains related viruses with different DNA genomes. Genomic diversity of pleolipoviruses includes single-stranded and double-stranded DNA molecules and their combinations as linear or circular molecules. To date, only eight viruses belong to the familyPleolipoviridae. In order to obtain more information about the diversity of pleolipoviruses, further isolates are needed. Here we describe the characterization of a new halophilic virus isolate,Haloarcula hispanicapleomorphic virus 4 (HHPV4). All pleolipoviruses and related proviruses contain a conserved core of approximately five genes designating this virus family, but the sequence similarity among different isolates is low. We demonstrate that over half of HHPV4 genome is identical to the genome of pleomorphic virus HHPV3. The genomic regions encoding known virion components are identical between the two viruses, but HHPV4 includes unique genetic elements, e.g., a putative integrase gene. T...Continue Reading

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Citations

Mar 29, 2019·Environmental Microbiology·Carolina M MizunoHanna M Oksanen
Jun 26, 2020·Archives of Virology·Tatiana A Demina, Hanna M Oksanen
Jan 28, 2021·Microorganisms·Sabine SchwarzerTessa E F Quax

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Datasets Mentioned

BETA
KY264020

Methods Mentioned

BETA
light-scattering
light scattering
electrophoresis
PCR
Assay
Infection

Software Mentioned

COILS
Blastx
Geneious
- blast
Glimmer
BLAST
Delta
GeneMarkS
Finder
ExPASy

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