The Unforeseen Non-Coding RNAs in Head and Neck Cancer

Genes
Alexandra Iulia IrimieIoana Berindan-Neagoe

Abstract

Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other "pieces of the RNA puzzle". These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis. Moreover, some are still considered housekeeping RNAs, for instance small nucleolar RNAs (snoRNAs) and TERC. Our review summarizes the biogenesis, mechanism of action and potential role of less known ncRNAs in head and neck cancer, with a particular focus on the installment and progress for this particular cancer type.

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Citations

Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Aug 14, 2020·International Journal of Molecular Sciences·Kacper GuglasKatarzyna Lamperska
Oct 22, 2018·Journal of Experimental & Clinical Cancer Research : CR·Cornelia BraicuIoana Berindan-Neagoe
Aug 23, 2020·International Journal of Molecular Sciences·Alina-Andreea ZimtaCiprian Tomuleasa
Jul 26, 2018·International Journal of Environmental Research and Public Health·Alexandra Iulia IrimieIoana Berindan-Neagoe
Mar 8, 2020·International Journal of Molecular Sciences·Enrico GaffoStefania Bortoluzzi
Jan 30, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rares DrulaIoana Berindan-Neagoe

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Methods Mentioned

BETA
RNA-Seq
reverse transcription PCR
transfection
RNASeq

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