The unfulfilled gene is required for the development of mushroom body neuropil in Drosophila.

Neural Development
Karen E BatesS Robinow

Abstract

The mushroom bodies (MBs) of Drosophila are required for complex behaviors and consist of three types of neurons, gamma, alpha'/beta' and alpha/beta. Previously, roles for transcription factors in MB neuronal differentiation have only been described for a subset of MB neurons. We are investigating the roles of unfulfilled (unf; HR51, CG16801) in MB development. unf encodes a nuclear receptor that is orthologous to the nuclear receptors fasciculation of axons defective 1 (FAX-1) of the nematode and photoreceptor specific nuclear receptor (PNR) of mammals. Based on our previous observations that unf transcripts accumulate in MB neurons at all developmental stages and the presence of axon pathfinding defects in fax-1 mutants, we hypothesized that unf regulates MB axon growth and pathfinding. We show that unf mutants exhibit a range of highly penetrant axon stalling phenotypes affecting all neurons of the larval and adult MBs. Phenotypic analysis of unfX1 mutants revealed that alpha'/beta' and alpha/beta neurons initially project axons but stall prior to the formation of medial or dorsal MB lobes. unfZ0001 mutants form medial lobes, although these axons fail to branch, which results in a failure to form the alpha or alpha' dorsal l...Continue Reading

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Citations

Oct 19, 2013·BMC Neuroscience·Matthew Laviolette, Bryan A Stewart
Apr 1, 2015·The Journal of Cell Biology·Dominique SiegenthalerJan Pielage
Nov 22, 2011·Gastrointestinal Endoscopy Clinics of North America·Joel V Brill
Jun 24, 2014·Biochimica Et Biophysica Acta·Karen E BatesSteven Robinow
Aug 28, 2012·Current Biology : CB·Shiri P YanivOren Schuldiner
Jun 29, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Shiri P Yaniv, Oren Schuldiner

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Methods Mentioned

BETA
gene knock down
PCR
transgenic
genotyping

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