PMID: 9193142Jan 1, 1997Paper

The unipolar brush cells of the mammalian cerebellum and cochlear nucleus: cytology and microcircuitry

Progress in Brain Research
E MugnainiD Jaarsma

Abstract

The unipolar brush cell (UBC) is a novel type of small neuron that is characterized by sets of morphological and chemical phenotypes. UBCs occur in the granular layer of the mammalian cerebellar cortex, particularly in folia of the vestibulocerebellum, and in the granule cell domains of the dorsal cochlear nucleus. The UBC is characterized by a single dendrite that terminates with a brush-like tip of dendrioles. The soma, the dendritic stem, and especially the dendrioles emit short, non-synaptic appendages. The dendrioles represent the main synaptic apparatus of the UBC and articulate tightly with a single mossy fiber rosette forming a glomerular array characterized by an extraordinarily extensive synaptic contact. Electron microscopic and electrophysiological observations indicate that the unusual synaptic ultrastructure may produce entrapment of neurotransmitter in the synaptic cleft. While ionotropic glutamate receptors are enriched in correspondence of the postsynaptic density, metabotropic glutamate receptors are situated extrasynaptically and are particularly enriched at the appendages, which usually do not bear synaptic junctions. Some of the UBCs receive their input from choline acetyltransferase-positive mossy rosettes...Continue Reading

Citations

May 2, 2001·The Journal of Comparative Neurology·M G NunziE Mugnaini
Apr 4, 2002·Journal of Neurophysiology·Daniela BillupsN Traverse Slater
Jun 24, 2004·Journal of Neurophysiology·Fatemeh S AfshariIndira M Raman
Oct 26, 2007·Journal of Neurophysiology·Veeramuthu Balakrishnan, Laurence O Trussell
Feb 16, 2008·Annual Review of Neuroscience·Curtis C BellNathaniel B Sawtell
Jan 5, 2011·The European Journal of Neuroscience·Seth D KoehlerSusan E Shore
Dec 16, 2000·The Journal of Comparative Neurology·D Soares, C E Carr
Dec 20, 2002·Acta Physiologica Hungarica·G Szucs, Z Rusznák
Mar 24, 2007·The Journal of Physiology·Marco J RussoMarco Martina
Sep 6, 2014·Frontiers in Cellular Neuroscience·Sathyaa SubramaniyamEgidio D'Angelo
Mar 1, 2005·The Journal of Comparative Neurology·Charles-André HaenggeliDavid K Ryugo
May 18, 2007·Annual Review of Cell and Developmental Biology·Roy V Sillitoe, Alexandra L Joyner
Mar 28, 2006·The Journal of Comparative Neurology·Xiping ZhanDavid K Ryugo
Apr 17, 2007·The Journal of Comparative Neurology·Holly R CampbellCurtis C Bell
May 7, 2020·Frontiers in Computational Neuroscience·Lingling AnJian K Liu
Nov 18, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J VígJ Hámori
Jun 8, 2000·The Journal of Comparative Neurology·M G Nunzi, E Mugnaini
Jun 22, 2000·Journal of Neuroscience Research·J TakácsJ Hámori
May 23, 2001·Progress in Neurobiology·N C Danbolt
Apr 23, 2004·Trends in Neurosciences·Donata Oertel, Eric D Young
Nov 6, 2008·Journal of Physiology, Paris·Nathaniel B Sawtell, Curtis C Bell
Oct 13, 2010·Brain Research Reviews·Enrico MugnainiMarco Martina

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