The Unique and Combined Effects of Apathy and Depression on Cognition in Parkinson's Disease

Journal of Parkinson's Disease
Matthew L CohenJason Brandt

Abstract

Apathy and depression are associated with poor cognition in patients with Parkinson's disease (PD). However, the cognitive signature of each syndrome is not well understood. The cognitive consequences of having apathy or depression, versus apathy and depression, are also unclear. This study investigated the unique and combined effects of apathy and depression on cognition in PD patients. PD patients were identified from a clinical research database as having self-reported apathy (n = 21), depression (n = 11), or both (n = 43). PD patients without apathy or depression served as the Control group (n = 49). The groups were of similar age, education, disease severity, age of symptom onset, and medication status. A multivariate analysis of variance (MANOVA) compared the groups on 17 neuropsychological test scores in the domains of attention, motor and psychomotor speed, construction, language, episodic memory, and executive functioning. There was a significant overall effect of group: F(18,276) = 2.12, p = 0.006, ηp2=0.12. Univariate analyses and planned contrasts revealed medium-sized effects distinguishing only the control group and the group with both apathy and depression (ηp2=0.06-0.12) on measures of verbal fluency and manual,...Continue Reading

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Citations

Jul 5, 2016·Neuroscience and Biobehavioral Reviews·Tetsuya AsakawaYing Xia
Oct 17, 2017·Journal of the International Neuropsychological Society : JINS·Sarah M SzymkowiczDawn Bowers
May 31, 2019·Journal of Neural Transmission·Anna Nagy, Anette Schrag
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Oct 23, 2019·Journal of Geriatric Psychiatry and Neurology·Monique A PimontelFaith M Gunning
Dec 18, 2020·Frontiers in Aging Neuroscience·Sandra BaezAdolfo M García
Jan 20, 2021·Journal of Geriatric Psychiatry and Neurology·Sarah M SzymkowiczPamela E May

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