The Unique Metabolic Characteristics of Bone Marrow Adipose Tissue

Frontiers in Endocrinology
Yujue LiXijie Yu

Abstract

Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situated in bone marrow space and resided with bone tissue side-by-side. MAT is considered not only as a regulator of bone metabolism through paracrine, but also as a functionally particular adipose tissue that may contribute to global metabolism. Adipokines, inflammatory factors and other molecules derived from bone marrow adipocytes may exert systematic effects. In this review, we summary the evidence from several aspects including development, distribution, histological features and phenotype to elaborate the basic characteristics of MAT. We discuss the association between bone metabolism and MAT, and highlight our current understanding of this special adipose tissue. We further demonstrate the probable relationship between MAT and energy metabolism, as well as glucose metabolism. On the basis of preliminary results from animal model and clinical studies, we propose that MAT has its unique secretory and metabolic function, although there is no in-depth study at present.

References

Jan 1, 1979·American Journal of Hematology·A BathijaS Trubowitz
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E Zakaria, E Shafrir
Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
May 20, 1998·Nature·P KristensenS Hastrup
Jun 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P LaharragueL Casteilla
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Aug 11, 2000·Science·S E RossO A MacDougald
Nov 9, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P LaharragueL Casteilla
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Mar 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Souhila AhdjoudjPierre J Marie
May 22, 2002·The Journal of Clinical Investigation·Takafumi YokotaPaul W Kincade
Jun 11, 2002·The Journal of Biological Chemistry·Christina N BennettOrmond A MacDougald
Jan 10, 2003·Clinical Endocrinology·M L DelporteM Lambert
Nov 1, 2003·Biochemical and Biophysical Research Communications·Mikael RydénKatarina Le Blanc
Apr 7, 2004·The Journal of Clinical Investigation·Toru AkuneHiroshi Kawaguchi
Oct 20, 2004·British Journal of Haematology·Jill CorrePatrick Laharrague
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark W HamrickClifton A Baile
Sep 7, 2005·Cell·Loning FuGerard Karsenty
Apr 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Ann V SchwartzSteven R Cummings
May 25, 2006·Journal of Cellular Biochemistry·Liv ThommesenUnni Syversen
Aug 1, 2006·Progress in Brain Research·Loning FuGerard Karsenty
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Clifford J Rosen, Mary L Bouxsein
Sep 15, 2006·Journal of Cellular Physiology·Sergiu Botolin, Laura R McCabe
Dec 30, 1898·The Journal of Physiology·R Stockman
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiang-Hang LuoEr-Yuan Liao
Dec 2, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W ShenS B Heymsfield
Mar 7, 2007·Calcified Tissue International·H XieE-Y Liao
Apr 10, 2007·Seminars in Nuclear Medicine·Judy S BlebeaAbass Alavi
Aug 8, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Weimin QiuMoustapha Kassem
Feb 16, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F A SyedS Khosla
Apr 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Natascia Di IorgiVicente Gilsanz

❮ Previous
Next ❯

Citations

Nov 18, 2019·Current Osteoporosis Reports·Markus Herrmann
Mar 4, 2020·International Journal of Molecular Sciences·Sukanya SureshConstance Tom Noguchi
Apr 28, 2020·Clinical Science·Marianna SantopaoloPaolo Madeddu
Jun 17, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lorena Doretto-SilvaLuciano de Melo Pompei
Jul 15, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Zhijia TanKathryn S E Cheah
Nov 22, 2019·Current Osteoporosis Reports·Hanel Sadie-Van Gijsen
Nov 22, 2019·Current Osteoporosis Reports·Michaela TencerovaMoustapha Kassem
Sep 27, 2020·Bone·Meshail Okla, Moustapha Kassem
Nov 14, 2020·Current Opinion in Rheumatology·Natalia Zapata-LinaresXavier Houard
Jan 6, 2021·Nature Metabolism·Nick van Gastel, Geert Carmeliet
Oct 23, 2020·Nutrition & Metabolism·Yang XiaoElizabeth R Gilbert
Nov 9, 2020·Molecular Aspects of Medicine·George HajishengallisTriantafyllos Chavakis
Aug 29, 2020·Mechanisms of Ageing and Development·Napatsorn ImerbSiriporn C Chattipakorn
Apr 9, 2021·Physics in Medicine and Biology·Florian GuillaumeGuillaume Haïat
Sep 29, 2021·Obesity·Kiley B Vander WystGabriel Q Shaibi
Oct 9, 2021·Bone·Tareq Anani, Alesha B Castillo
Feb 4, 2022·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Alison FlehrMattias Lorentzon

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knockout
flow cytometry
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Endocrinology and Metabolism : TEM
Erica L SchellerO A MacDougald
Annals of the New York Academy of Sciences
Erica L Scheller, Clifford J Rosen
Adipocyte
Mark C HorowitzClifford J Rosen
The Journal of Clinical Endocrinology and Metabolism
Skorn PonrartanaVicente Gilsanz
British Journal of Pharmacology
Vera FranciscoOreste Gualillo
© 2022 Meta ULC. All rights reserved