The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment

Clinical Reviews in Allergy & Immunology
Alexandra Leonard, Emma Guttman-Yassky

Abstract

Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., nickel and fragrance) in human skin has shown that different allergens have distinct molecular fingerprinting. For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD. While ACD has previously been considered to be constant across all allergens, largely based on mouse models involving strong sensitizers, these new data suggest that ACD differs mechanistically according to allergen. Further, ACD in the setting of concurrent AD shows a different and attenuated phenotype as compared to healthy individuals with ACD, which influences the way AD patients respond to vaccination and other treatment modalities. As in contact sensitization, skin challenged by food patch testing shows that common food allergens (e.g., peanut and barley) also cause distinct...Continue Reading

References

Jul 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C NeumannF Herrmann
Jun 27, 2003·International Archives of Occupational and Environmental Health·Ai-Lean Chew, Howard I Maibach
Jul 4, 2003·The Journal of Investigative Dermatology·Heinrich DickelThomas L Diepgen
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Eleonora CandiGerry Melino
Feb 4, 2006·The Journal of Investigative Dermatology·Marc VocansonJean-François Nicolas
Feb 3, 2007·The Journal of Investigative Dermatology·Marlene BonnevilleAna Hennino
Apr 18, 2008·Contact Dermatitis·Cindy M de JonghSanja Kezic
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Stefan F Martin, Thilo Jakob
Feb 17, 2009·Human Immunology·Kerstin SteinbrinkHelmut Jonuleit
May 19, 2009·European Journal of Dermatology : EJD·Audrey NosbaumJean-François Nicolas
Jul 8, 2009·Dermatologic Clinics·Shane C Clark, Matthew J Zirwas
Sep 2, 2009·The Journal of Allergy and Clinical Immunology·Michael D HowellDonald Y M Leung
Oct 21, 2009·Allergy·M VocansonJ-F Nicolas
Dec 17, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L MondouletP-H Benhamou
Feb 9, 2010·Contact Dermatitis·Jacob P ThyssenTorkil Menné
Feb 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan P LarsonSteven F Ziegler
Mar 11, 2011·The Journal of Allergy and Clinical Immunology·Mayte Suárez-FariñasEmma Guttman-Yassky
May 21, 2011·Journal of the American Academy of Dermatology·Erin M WarshawUNKNOWN North American Contact Dermatitis Group, 1994-2008
Oct 1, 2011·Archives of Dermatological Research·Sonia C DaSilvaJeffrey B Travers
Jan 14, 2012·Nature Reviews. Immunology·Daniel H KaplanAnthony A Gaspari
Mar 6, 2012·The Journal of Allergy and Clinical Immunology·Saeko NakajimaKenji Kabashima
Mar 13, 2012·Contact Dermatitis·Lilla LandeckSwen M John
Apr 26, 2012·Experimental Animals·Akane TanakaHiroshi Matsuda
Aug 31, 2012·The Journal of Investigative Dermatology·Tetsuya HondaKenji Kabashima
Sep 4, 2012·The Journal of Allergy and Clinical Immunology·Julia K GittlerEmma Guttman-Yassky
Mar 27, 2013·The Journal of Investigative Dermatology·Louise NewellMichael R Ardern-Jones
Apr 16, 2013·Journal of the American Academy of Dermatology·Dana Malajian, Donald V Belsito
Jun 20, 2013·The Journal of Allergy and Clinical Immunology·Mayte Suárez-FariñasEmma Guttman-Yassky
Sep 12, 2013·Clinical & Developmental Immunology·Matthias Peiser
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Nikhil DhingraEmma Guttman-Yassky
Jul 16, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Tali CzarnowickiEmma Guttman-Yassky
Oct 9, 2014·The Journal of Clinical Investigation·Leticia TordesillasM Cecilia Berin
Dec 3, 2014·Immunology and Allergy Clinics of North America·Jessica Savage, Christina B Johns
Jan 15, 2015·The Journal of Allergy and Clinical Immunology·Joel Correa da RosaEmma Guttman-Yassky
Apr 13, 2015·The Journal of Allergy and Clinical Immunology·Jenny SeltmannThomas Werfel
Sep 18, 2015·Lancet·Stephan Weidinger, Natalija Novak
Oct 3, 2015·The Journal of Allergy and Clinical Immunology·Shinji NodaEmma Guttman-Yassky
Oct 30, 2016·Current Opinion in Immunology·Beatriz Cabanillas, Natalija Novak
Oct 30, 2016·The British Journal of Dermatology·R BissonnetteW C Ports
Aug 5, 2016·Experimental Dermatology·Benjamin UngarEmma Guttman-Yassky
Sep 28, 2016·The Journal of Allergy and Clinical Immunology·Hitokazu EsakiEmma Guttman-Yassky
Oct 6, 2016·The Journal of Allergy and Clinical Immunology·David A EwaldEmma Guttman-Yassky
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pierre-Louis HervéSabine Riffault
Oct 25, 2016·The Journal of Investigative Dermatology·Patrick M BrunnerUNKNOWN Councilors of the International Eczema Council

❮ Previous
Next ❯

Citations

Jul 19, 2019·Immunological Medicine·Hiraku Suga, Shinichi Sato
Nov 7, 2019·The Journal of Dermatological Treatment·Aleksi J HendricksVivian Y Shi
Oct 28, 2019·Immunity, Inflammation and Disease·Yasunari KageyamaTsutomu Nakamura
Aug 4, 2020·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Susan Bishop, Howard Roberts
Jun 13, 2020·Modern Rheumatology·Yoshiya Tanaka
Nov 9, 2018·Frontiers in Immunology·Fanny Lafouresse, Joanna R Groom
Jan 8, 2021·Therapeutics and Clinical Risk Management·Celina DubinEmma Guttman-Yassky
Nov 3, 2020·Dermatology Research and Practice·Anna TagkaDimitrios Rigopoulos
Oct 23, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kanwaljit K Brar
Apr 8, 2019·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
Aug 10, 2019·The Journal of Allergy and Clinical Immunology·Ting-Lin B Yang, Brian S Kim
Jul 16, 2021·Clinical Reviews in Allergy & Immunology·Yan Li, Linfeng Li
Jul 16, 2021·Journal of Cutaneous Medicine and Surgery·Lina BelmeskElena Netchiporouk
Aug 31, 2021·Frontiers in Pharmacology·Yiwei ZhangXianying Fang
Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song
Dec 17, 2021·Asthma Research and Practice·Martina Yaneva, Razvigor Darlenski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.