The unique structural and functional features of CXCL12

Cellular & Molecular Immunology
Rik JanssensPaul Proost

Abstract

The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration of hematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity is tightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans, each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNA stability determine the CXCL12 expression profile. CXCL12 fulfills its functions in homeostatic and pathological conditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a proper presentation to passing leukocytes. Homodimerizaton and heterodimerization of CXCL12 and its receptors can alter their signaling activity, as exemplified by the synergy between CXCL12 and other chemokines in leukocyte migration assays. Receptor binding may also initiate CXCL12 internalization and its subsequent removal from the environment. Furthermore, CXCL12 act...Continue Reading

References

Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J SicilianoM S Springer
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Aug 14, 1999·The Journal of Biological Chemistry·A AmaraF Arenzana-Seisdedos
Dec 30, 1999·American Journal of Respiratory Cell and Molecular Biology·E SatoR A Robbins
Nov 23, 2000·The Journal of Biological Chemistry·R SadirH Lortat-Jacob
Mar 29, 2001·Nature Immunology·M Thelen
Mar 10, 2001·European Journal of Immunology·M B DelgadoM Wolf
Jul 4, 2001·Advances in Immunology·O YoshieH Nomiyama
Sep 26, 2001·The Journal of Biological Chemistry·G A McQuibbanC M Overall
Sep 29, 2001·Nature Immunology·C Bogdan
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K S AulakD J Stuehr
Feb 28, 2002·The Journal of Biological Chemistry·Agustín Valenzuela-FernándezFernando Arenzana-Seisdedos
Jul 12, 2002·Arthritis Research·Günter Steiner, Josef Smolen
Nov 16, 2002·The Journal of Biological Chemistry·Gregory J BabcockJoseph Sodroski
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kent W ChristophersonHal E Broxmeyer
Jan 22, 2003·Journal of Immunological Methods·Christine A Power
May 6, 2003·European Journal of Immunology·Silvia F SorianoMario Mellado
Oct 28, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Erik R VossenaarGer J M Pruijn
Nov 5, 2003·The Journal of Experimental Medicine·Tiziana SchioppaAntonio Sica
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
May 19, 2004·Immunology·Gloria SoldevilaEduardo García-Zepeda
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Aug 18, 2004·Science·Kent W ChristophersonHal E Broxmeyer

❮ Previous
Next ❯

Citations

Feb 7, 2018·International Journal of Molecular Sciences·Daiane BoffPaul Proost
Mar 27, 2018·Cellular & Molecular Immunology·Peng Tang, Ji Ming Wang
Sep 7, 2019·Journal of Molecular Neuroscience : MN·Jun TianZaiwang Zhang
Aug 11, 2019·British Journal of Pharmacology·Argen MamazhakypovSudarshan Rajagopal
Jan 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin-Jiang LuJiong Chen
Apr 3, 2020·Cellular & Molecular Immunology·Mieke MetzemaekersPaul Proost
Apr 9, 2020·Vaccines·Stefania ScalaElena Monica Borroni
May 27, 2020·SLAS Technology·William P Vignovich, Vitor H Pomin
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irena WielebaPaweł Krawczyk
Aug 31, 2019·Journal of Cellular and Molecular Medicine·Fang-Yang HuangMao Chen
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Assem AshimovaGonzalo Hortelano
Apr 17, 2020·Frontiers in Immunology·Helena CrijnsPaul Proost
Aug 15, 2020·Frontiers in Immunology·Blair Z JohnsonVanessa S Fear
Jul 6, 2019·Journal of Oncology·Alessandra RighettiFrancesco Piva
Oct 21, 2018·Pharmaceuticals·Mario M SoldevillaFernando Pastor
Sep 8, 2020·Journal of Tissue Engineering and Regenerative Medicine·Franziska ClauderAnnette G Beck-Sickinger
Nov 24, 2020·Cancer Investigation·Hassan RafieemehrNajmaldin Saki
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Shan LinDongxiao Sun
Dec 2, 2020·Molecular Human Reproduction·Teruhiko KawamuraKiyoko Kato
Jan 14, 2021·Cancers·Teru Hideshima, Kenneth C Anderson
Jan 28, 2021·Cell·Xiu NieTiannan Guo
Jan 13, 2021·Scientific Reports·Elisabeth HofmannPetra Kotzbeck
Jan 19, 2021·Stem Cells International·Meichen LiuJinlan Jiang
Oct 25, 2020·Cancers·Karolina A Zielińska, Vladimir L Katanaev
Feb 4, 2021·Cancers·Juan Carlos López-GilBruno Sainz
Dec 8, 2020·Frontiers in Endocrinology·Irina ChifuStefanie Hahner
Mar 23, 2021·Frontiers in Veterinary Science·Julie BenningtonJ Koudy Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.