The unknown face of IRE1α - Beyond ER stress

European Journal of Cell Biology
Ahmad Abdullah, Palaniyandi Ravanan

Abstract

IRE1α (Inositol Requiring kinase Enzyme 1 alpha), a transmembrane protein localized to the endoplasmic reticulum (ER) is a master regulator of the unfolded protein response (UPR) pathway. The fate determining steps during ER stress-induced apoptosis are greatly attributed to IRE1α's endoribonuclease and kinase activities. Apart from its role as a chief executioner in ER stress, recent studies have shown that upon activation in the presence or absence of ER stress, IRE1α executes multiple cellular processes such as differentiation, immune response, progression and repression of the cell cycle. Besides its crucial role in protein misfolding, the versatile contributions of IRE1α in other cellular functions are greatly unknown. In this review, we have discussed the structural conservation of IRE1 among eukaryotes, the mechanisms underlying its activation and the recent understandings of the non-apoptotic functions of IRE1 other than ER stress-induced cell death.

Citations

Feb 6, 2019·The FEBS Journal·Ahmad AbdullahPalaniyandi Ravanan
Dec 5, 2019·Endocrinology·Irina X ZhangLeslie S Satin
Nov 5, 2019·Journal of Experimental Botany·Taiaba AfrinKarolina Pajerowska-Mukhtar
Apr 13, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenAnu Kauppinen
Sep 10, 2019·Emerging Microbes & Infections·Cornelius RohdeVerena Krähling
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Dec 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh YarmohammadiGholamreza Karimi
Dec 29, 2020·Frontiers in Pharmacology·José Miguel Vela
Apr 4, 2021·International Journal of Molecular Sciences·Bingting YuMaikel P Peppelenbosch
Dec 29, 2020·Current Opinion in Virology·Jeanmarie Verchot, Karolina M Pajerowska-Mukhtar
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yingying ShiJian You
Jun 26, 2021·Frontiers in Aging Neuroscience·Haigang RenGuanghui Wang

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Apoptosis

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