The unmasking of 'junk' RNA reveals novel sRNAs: from processed RNA fragments to marooned riboswitches

Current Opinion in Microbiology
Nicholas R De Lay, Danielle A Garsin

Abstract

While the notion that RNAs can function as regulators dates back to early molecular studies of gene regulation of the lac operon, it is only over the last decade that the ubiquity and diversity of regulatory RNAs are being realized. Advancements in high throughput sequencing and the adoption of these approaches to rapidly sequence genomes and transcriptomes and to examine gene expression and RNA binding protein specificity have revealed an ever-expanding RNA world. In this review, we focus on recent studies revealing that RNA fragments cleaved from larger coding or noncoding RNAs can have regulatory functions. Additionally, we discuss examples of riboswitches that function in trans as mRNA or protein-binding sRNAs, upending the traditional thinking that these are exclusively cis-acting elements.

References

Sep 26, 1991·Nature·U von AhsenR Schroeder
May 11, 1973·Molecular and Cellular Biochemistry·S Altman, H D Robertson
Sep 8, 1971·Nature: New Biology·S Altman, J D Smith
Jan 6, 1971·Nature: New Biology·S Altman
Jan 14, 1971·Journal of Molecular Biology·A E Dahlberg, A C Peacock
Jul 11, 2001·Genes & Development·K M WassarmanS Gottesman
Jul 13, 2001·Current Biology : CB·L ArgamanS Altuvia
Feb 14, 2002·Trends in Biochemical Sciences·Chengyi J Shu, Igor B Zhulin
Jul 19, 2003·The Journal of Biological Chemistry·Dmitry A RodionovMikhail S Gelfand
Nov 19, 2003·Molecular Microbiology·Aixia ZhangSusan Gottesman
Jun 25, 2004·Nucleic Acids Research·Dmitry A RodionovMikhail S Gelfand
Oct 24, 2007·BMC Molecular Biology·Marion ScheibeMario Mörl
Jan 31, 2008·RNA·Taewoo Lee, Andrew L Feig
Feb 6, 2008·FEMS Microbiology Letters·Silvana V SpinelliFernando C Soncini
Sep 9, 2008·Journal of Bacteriology·María Florencia Del Papa, Marta Perego
Feb 26, 2009·Cell·Lauren S Waters, Gisela Storz
Nov 26, 2009·Genes & Development·Yong Sun LeeAnindya Dutta
Apr 12, 2011·Molecular Microbiology·Laurène BastetDaniel A Lafontaine
Aug 31, 2011·PLoS Computational Biology·David N Adamson, Han N Lim
Sep 20, 2011·Molecular Cell·Ronald R Breaker
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kerry HollandsEduardo A Groisman
Jun 12, 2012·PLoS Genetics·Arati RameshWade C Winkler
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marie-Pier CaronDaniel A Lafontaine
Jan 18, 2013·Archaea : an International Microbiological Journal·Jennifer GebetsbergerNorbert Polacek
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·J R MellinPascale Cossart
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kerry HollandsEduardo A Groisman
Aug 26, 2014·Science·Jiandong Chen, Susan Gottesman
Jan 23, 2015·MicrobiologyOpen·Anubrata GhosalPaul Wilmes
Feb 25, 2015·Trends in Genetics : TIG·J R Mellin, Pascale Cossart

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Citations

Mar 23, 2017·Journal of Extracellular Vesicles·Bogdan MateescuEsther N M Nolte-'t Hoen
Feb 22, 2018·MBio·Karan Gautam Kaval, Danielle A Garsin
Mar 9, 2018·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Payal SinghHemant Ritturaj Kushwaha
Apr 18, 2019·Nucleic Acids Research·Hendrik MeliorElena Evguenieva-Hackenberg
Mar 6, 2019·Journal of Bacteriology·Karan Gautam KavalDanielle A Garsin
Jun 1, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Cristina Carvalho BarbosaHans-Joachim Wieden
Jan 4, 2020·The Journal of Microbiology·Jun RenDokyun Na
Feb 10, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Anne-Sophie Vézina BédardDaniel A Lafontaine
Jul 3, 2021·Frontiers in Plant Science·Bhavika TiwariWolfgang Frank

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