PMID: 7547529Jan 1, 1994Paper

The UNOS Scientific Renal Transplant Registry. United Network for Organ Sharing

Clinical Transplants
J M Cecka, P I Terasaki

Abstract

1. The number of cadaveric transplants performed each year at United States transplant centers has increased very little, from 7,200 in 1988 to 8,100 in 1993. Living-donor transplants increased during the same period from 1,656 to 2,562. 2. The recipient and donor populations have aged since UNOS began collecting data. In 1988, 39% of first-cadaver transplant recipients were over age 45 compared with 45% in 1993. During the same period, the percentage of cadaver kidneys from donors over age 45 increased from 16% to 26%. 3. Recipients over age 60 or under age 19 had 65% 3-year graft survival rates compared with 70% for those in the intervening age groups (p < 0.001). As many as 60% of graft failures after the first year were accounted for by deaths with a functioning graft when the recipient was over 60 compared with less than 15% when the patient was under age 30 (p < 0.01). Rejection caused 45% of graft failures after the first year for recipients under age 45 but only 17% in those over 60 (p < 0.01). When deaths were censored in the graft survival calculation, recipients over age 45 had the highest 3-year survival rate of 79% compared with 72% for those aged 6-18 (p < 0.001). 4. The 3-year graft survival rate for kidneys from...Continue Reading

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