Feb 25, 2020

The up-to-date role of biologics for the treatment of chronic lymphocytic leukemia

Expert Opinion on Biological Therapy
I HusTadeusz Robak


Chronic lymphocytic leukemia (CLL) is a genetically complex disease that affects a heterogeneous patient population. Therapeutic armamentarium of CLL has changed recently following the introduction of novel active agents. This review presents the current state of knowledge about biologic drugs used in the treatment of patients with CLL. It also discusses the biologics under evaluation in clinical trials and their potential future perspectives. A literature review of the MEDLINE database for articles was conducted via PubMed. Publications from 2000 through October 2019 were scrutinized using the search terms monoclonal antibodies, alloHSCT, vaccines and CAR-T in conjunction with CLL. Conference proceedings from the previous five years of the ASH and EHA Annual Scientific Meetings were searched manually. Additional relevant publications were obtained by reviewing the references from the chosen articles. When used in combination with chemotherapy and, more recently, with the Bcl-2 inhibitor venetoclax, anti-CD20 monoclonal antibodies (mAbs) are among the standard methods used for CLL treatment. Among the new mAbs, anti-ROR1 directed cirmtuzumab seems to have the most promising results. Adoptive immunotherapy with CAR-T is an area ...Continue Reading

  • References93
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Adoptive Immunotherapy
Biological Factors
Clinical Trials
Chronic Lymphocytic Leukaemia Refractory
Chronic Lymphocytic Leukemia
Monoclonal Antibodies

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

Ryōikibetsu shōkōgun shirīzu
S Ito, S Kuriya
Oncology Research and Treatment
Othman Al-SawafMichael Hallek
© 2020 Meta ULC. All rights reserved