The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zili ZhangShizhong Zheng

Abstract

Autophagy is a genetically programmed, evolutionarily conserved catabolic process that occurs in response to stress. While short-lived proteins are degraded via the ubiquitin/proteasome pathway in higher eukaryotes, autophagy refers to intracellular pathway for development, differentiation, survival, and homeostasis through the lysosomal-dependent machinery, which regulates the synthesis, degradation, and recycling of long-lived proteins and even whole cytoplasmic organelles. The newly discovery shows that autophagy plays an important role in recycling nutrients upon starvation and maintaining cellular energy homeostasis. Recent basic and clinical investigations further demonstrate that autophagic abnormalities have been considered underlying reasons for lots of human diseases, including liver disease, cardiovascular and cerebrovascular diseases, neurodegenerative diseases, neoplastic diseases, and cancers. Pharmacological modulation of autophagy might point to possible therapeutic strategies for combating a broad range of diseases. Regrettably, although the mechanisms underlying the regulation of autophagy have long been attracted extensive concern of numerous scholars and its acute regulation by nutrient-sensing signaling pat...Continue Reading

References

Apr 28, 2005·Current Biology : CB·Daniel J Klionsky
May 2, 2007·Autophagy·Mojgan Djavaheri-MergnyPatrice Codogno
Jun 20, 2007·Molecular and Cellular Biology·Kristin TracyKay F Macleod
Jun 30, 2009·Journal of Cellular Biochemistry·J C Gallardo-PérezV Maldonado
Aug 4, 2009·Archives of Biochemistry and Biophysics·Yahong ZhangTakashi Ikejima
Aug 22, 2009·The Journal of Biological Chemistry·Arunima SenguptaKatherine E Yutzey
Jun 26, 2010·Journal of Cardiovascular Translational Research·Anwarul FerdousJoseph A Hill
Dec 4, 2010·Science·Joshua D Rabinowitz, Eileen White
Feb 18, 2011·Genes & Development·Ping XuRoger J Davis
May 28, 2011·Science·Carmine SettembreAndrea Ballabio
Jun 10, 2011·Nature Reviews. Molecular Cell Biology·Rachel David
Dec 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kyeongjin KimSung Hee Um
Jan 27, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiyoung LeeJongsook Kim Kemper
Feb 15, 2012·Autophagy·Ágnes BánrétiMiklós Sass
Jun 14, 2012·Science Signaling·Agnes Roczniak-FergusonShawn M Ferguson
Jul 24, 2012·Nature Cell Biology·Kristan E van der VosPaul J Coffer
Jul 25, 2012·Cancer Biology & Therapy·Aracely Garcia-GarciaJorge G Gomez-Gutierrez
Sep 7, 2012·PloS One·Jessica A WilliamsGrace L Guo
Feb 23, 2013·Biochimica Et Biophysica Acta·Jianzhou CuiHan-Ming Shen
Apr 2, 2013·Molecular and Cellular Endocrinology·S Haricharan, Y Li
Apr 23, 2013·EMBO Molecular Medicine·Carmine SpampanatoNina Raben
Jun 13, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Paula-GomesI C Kettelhut
Jun 19, 2013·Journal of Innate Immunity·Daniel J Klionsky, Patrice Codogno

❮ Previous
Next ❯

Citations

Jan 16, 2016·The British Journal of Surgery·J R AunanK Søreide
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shifei WuTao Guo
Jan 14, 2017·Expert Opinion on Therapeutic Targets·Jinghan FengJiangang Shen
Aug 17, 2016·Journal of Cell Science·Jens FüllgrabeDavid C Rubinsztein
Jul 1, 2017·Cell Death Discovery·Xiaodong ZhouFranco Fortunato
Nov 24, 2020·Oxidative Medicine and Cellular Longevity·Natalia Jimenez-Moreno, Jon D Lane
Mar 8, 2021·Experimental Neurology·Xiaoyu WangJianmin Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Annals of the New York Academy of Sciences
Ameeta Kelekar
Acta Pharmacologica Sinica
Ya-ping YangZheng-Hong Qin
Cell Cycle
Marlène Dreux, Francis V Chisari
© 2021 Meta ULC. All rights reserved