The upregulation of cognate and inducible heat shock proteins in the anoxic turtle brain

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Howard M PrenticeP L Lutz

Abstract

Because heat shock proteins (HSPs) have an important protective function against ischemia/anoxia in mammalian brain, the authors investigated the expression of Hsp72 and Hsc73 in the anoxia-surviving turtle brain. Unlike the mammalian brain, high levels of Hsp72 were found in the normoxic turtle brain. Hsp72 levels were significantly increased by 4 hours of anoxia, remained constant until 8 hours, and then decreased to baseline at 12 hours. By contrast, Hsc73 was progressively increased throughout 12 hours of anoxia. This differential expression suggests different protective roles: Hsp72 in the initial downregulatory transition phase, and Hsc73 in maintaining neural network integrity during the long-term hypometabolic phase.

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Citations

Oct 17, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Anastasia Krivoruchko, Kenneth B Storey
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Anastasia Krivoruchko, Kenneth B Storey
Sep 8, 2015·Experimental Gerontology·Jamila R SanchezRochelle Buffenstein
Dec 2, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Jonathan A W StecykGöran E Nilsson
Aug 20, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Gillian M C RenshawShailendra Anoopkumar-Dukie
Nov 16, 2010·Journal of Insect Physiology·M Robert MichaudDavid L Denlinger
May 29, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sarah L MiltonHoward M Prentice
Jun 20, 2007·The Veterinary Clinics of North America. Exotic Animal Practice·David Martinez-Jimenez, Stephen J Hernandez-Divers
Mar 6, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A P Farrell, Jonathan A W Stecyk
May 30, 2009·Journal of Neurochemistry·Shailaja KesarajuSarah L Milton
Oct 13, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kenneth B Storey
Oct 20, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah L Milton, Howard M Prentice
Dec 3, 2005·Cryobiology·Kenneth B Storey
Apr 7, 2015·Archives of Biochemistry and Biophysics·Valentina R GarbarinoRochelle Buffenstein
Mar 5, 2015·Brain Research Bulletin·Thomas I NathanielAdebobola Imeh-Nathaniel
Mar 28, 2009·Neuroscience·L B Silverman-GavrilaZ-P Feng
Feb 11, 2015·Biochimica Et Biophysica Acta·Anastasia Krivoruchko, Kenneth B Storey
Jan 14, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Erdal İnDilara Kaman
Mar 19, 2016·Experimental Physiology·Gauri NayakSarah L Milton
Jun 27, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kåre-Olav StensløkkenGöran E Nilsson
Mar 26, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kåre-Olav StensløkkenGöran E Nilsson
Nov 27, 2008·Physiological Genomics·Howard M Prentice
Nov 6, 2012·Molecular and Cellular Biochemistry·Anastasia Krivoruchko, Kenneth B Storey
Oct 10, 2020·Cellular and Molecular Life Sciences : CMLS·Justyna Mikuła-PietrasikKrzysztof Książek
Mar 29, 2014·The Journal of Experimental Biology·John LarsonThomas J Park
May 10, 2007·The Journal of Experimental Biology·Kenneth B Storey, Janet M Storey
May 29, 2021·The Journal of Experimental Biology·Varshinie PillaiEbrahim Lari

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