The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise

Brain Research
Grace Sophia GriesbachDavid Allen Hovda

Abstract

Following traumatic brain injury (TBI), the brain undergoes a period of metabolic and neurochemical alterations that may compromise the reactivity of neuroplasticity-related molecular systems to physiological stimulation. In order to address the molecular mechanisms underlying plasticity following TBI and the effects of physical stimulation in the acute phase of TBI, levels of intracellular signaling molecules were assessed following voluntary exercise. Lateral fluid percussion injury (FPI) and sham-operated (Sham) rats were housed with or without access to a running wheel (RW) from postsurgery day 0 to 6. Parietal and occipital cortical tissues were analyzed for brain-derived neurotrophic factor (BDNF) using an enzyme-linked immunoabsorbant assay (ELISA). In addition, synapsin I, phospho-synapsin I, cyclic-AMP response-element-binding protein (CREB), phospho-CREB, calcium-calmodulin-dependent protein kinase II (CAMKII), mitogen-activated protein (MAP) kinase I and II (MAPKI and MAPKII), and protein kinase C (PKC) were analyzed by western blot. Results from this study indicated that FPI alone lead to significant increases in synapsin I, CAMKII, and phosphorylated (P) MAPKI (p44) and MAPKII (p42). Exercise in the sham operates l...Continue Reading

References

Jun 8, 1995·Nature·V A PieriboneP Greengard
Jan 12, 1995·Nature·S A NeeperC Cotman
Sep 1, 1994·Stroke; a Journal of Cerebral Circulation·W StummerO Kempski
Jan 1, 1993·Brain Research. Brain Research Reviews·J M BronsteinC G Wasterlain
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonA J Hansen
Apr 1, 1996·Neurochemistry International·T R Soderling
Dec 9, 1997·Neuron·S FinkbeinerM E Greenberg
Apr 8, 1998·Annual Review of Neuroscience·A J SilvaS Kida
Jul 4, 1998·Brain Research. Brain Research Reviews·T Abel, E Kandel
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
May 24, 2000·Cellular and Molecular Life Sciences : CMLS·S Finkbeiner
Jun 14, 2000·Current Opinion in Neurobiology·T R Soderling
Oct 18, 2002·The European Journal of Neuroscience·Raffaella MolteniFernando Gómez-Pinilla

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Citations

Sep 8, 2010·Intensive Care Medicine·Erica L Martin, V Marco Ranieri
Dec 12, 2012·Translational Stroke Research·Coleen M Atkins
Mar 28, 2013·Journal of Neurotrauma·Luiz Fernando Almeida SilvaLuiz Fernando Freire Royes
May 18, 2010·The Journal of Head Trauma Rehabilitation·Kurt A MossbergBrent E Masel
Jul 23, 2013·Journal of Neurologic Physical Therapy : JNPT·Michael R BorichNaznin Virji-Babul
Feb 27, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Darpan I Patel, Lesley J White
Oct 16, 2012·American Journal of Respiratory and Critical Care Medicine·Ramona O HopkinsDale Needham
Oct 8, 2013·PloS One·Mark E Maynard, J Leigh Leasure
Jun 5, 2008·Journal of Athletic Training·Cynthia W MajerskeAmy K Wagner
Aug 21, 2013·Journal of Athletic Training·Karl F KozlowskiBarry S Willer
Jan 22, 2014·International Journal of Molecular Sciences·Shruti V Kabadi, Alan I Faden
Apr 4, 2014·Journal of Neurotrauma·Elizabeth SteuerLeonardo Belluscio
Apr 29, 2010·The Physician and Sportsmedicine·Rosanna C Sabini, Cara Camiolo Reddy
May 8, 2015·Brain Injury : [BI]·Camille Larson-DupuisLouis De Beaumont
Oct 4, 2014·Brain Injury : [BI]·Rosemarie Scolaro MoserGrant L Iverson
Nov 24, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·David Fogelman, Ross Zafonte
Nov 5, 2011·Physical Medicine and Rehabilitation Clinics of North America·Daniel W ShreyChristopher C Giza
Nov 5, 2011·Physical Medicine and Rehabilitation Clinics of North America·Maegan D SadyGerard A Gioia
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Grace S Griesbach
Mar 30, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Coleen M AtkinsBing-Ren Hu
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Corina O BondiAnthony E Kline
Oct 6, 2007·Experimental Neurology·Coleen M AtkinsW Dalton Dietrich
Mar 15, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·John LeddyBarry Willer
Oct 3, 2008·Journal of Neuroscience Research·Grace Sophia GriesbachFernando Gomez-Pinilla
Mar 26, 2016·Frontiers in Neuroscience·Simona GradariJosé L Trejo
Dec 24, 2009·Alcoholism, Clinical and Experimental Research·J Leigh Leasure, Kimberly Nixon
Nov 22, 2005·Brain Research·Marcelo O DietrichLuis V Portela

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