The uptake and extrusion of monovalent cations by isolated heart mitochondria
The factors involved in the movement of monovalent cations across the inner membrane of the isolate heart mitochondrion are reviewed. The evidence suggests that the energy-dependent uptake of K+ and Na+ which results in swelling of the matrix is an electrophoretic response to a negative internal potential. There are no clear cut indications that this electrophoretic cation movement is carrier-mediated and possible modes of entry which do not require a carrier are examined. The evidence also suggests that the monovalent cation for proton exchanger (Na+ greater than K+) present in the membrane may participate in the energy-dependent extrusion of accumulated ions. The two processes, electrophoreti c cation uptake (swelling) and exchange-dependent cation extrusion (contraction) may represent a means of controlling the volume of the mitochondrion within the functioning cell. A number of indications point to the possibility that the volume control process may be mediated by the divalent cations Ca+2 and Mg+2. Studies with mercurial reagents also implicate certain membrane thiol groups in the postulated volume control process.
Effects of magnesium, Ruthenium red and the antibiotic ionophore A-23187 on initial rates of calcium uptake and release by heart mitochondria
Role of lipids in mitochondrial energy coupling: evidence from spin labeling and freeze-fracture electron microscopy
The mechanism of mitochondrial swelling. V. Permeability of mitochondria to alkali metal salts of strong acid anions
The effect of uncoupling agents and detergents on the movements of monovalent cations between mitochondria and medium
Swelling and shrinkage phenomena in liver mitochondria. V. Permeability of the mitochondrial membrane to univalent cations: effect of Mg++
Inhibition and activation of calcium transport in mitochondria. Effect of lanthanides and local anesthetic drugs
Studies on the role of Mg 2+ and the Mg 2+ -stimulated adenosine triphosphatase in oxidative phosphorylation
Ion transport by heart mitochondria. XXV. Activation of energy-linked K + uptake by non-ionic detergents
Dependency of the ATPase and 32 P--ATP exchange reaction of mitochondria on K + and electron transport
Quantitative electron microscopic description of heart muscle cells. Application to normal, hypertrophied and thyroxin-stimulated hearts
Ion transport by heart mitochondria. Retention and loss of energy coupling in aged heart mitochondria
Lipid oxidation in biological membranes. II. Kinetics and mechanism of lipid oxidation in submitochondrial particles
Adenine nucleotide-induced contraction of the inner mitochondrial membrane. I. General characterization
Hamster brown-adipose-tissue mitochondria. The chloride permeability of the inner membrane under respiring conditions, the influence of purine nucleotides
Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca++ uptake by cardiac mitochondria
Ion transport by heart mitochondria. XXVI. Carrier-mediated anion transport by isolated beef heart mitochondria
Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
Swelling and shrinkage phenomena in liver mitochondria. III. Irreversible swelling induced by inorganic phosphate and Ca2+
Ion transport by heart mitochondria. X. The uptake and release of Zn2+ and its relation to the energy-linked accumulation of magnesium
Ion transport in heart mitochondria. 8. The effect of ethylenediaminetertraacetate on monovalent ion uptake
Ion transport by heart mitochondria. XIV. The mannitol-impermeable compartment of the mitochondrion and its relation to ion uptake
Effect of ion conductance changes in the mitochondrial membrane on the kinetics of respiratory carriers
On the coupling between the transport of phosphate and adenine nucleotides in rat liver mitochondria
Ion transport by heart mitochondria. XXII. Spontaneous, energy-linked accumulation of acetate and phosphate salts of monovalent cations
Osmotically-induced alterations in volume and ultrastructure of mitochondria isolated from rat liver and bovine heart
Cation uptake as the basis for production of proton pulses by mitochondria at the anaerobic-aerobic transition
Differential effects of mercurial reagents on membrane thiols and on the permeability of the heart mitochondrion
Ion transport by heart mitochondria. XI. The spontaneous and induced permeability of heart mitochondria to cations
Expansion of the inner membrane compartment and its relation to mitochondrial volume and ion transport
Differential effects of mercurial reagents on mitochondrial thiol groups and mitochondrial permeability
The mechanism of mitochondrial swelling. II. Pseudoenergized swelling in the presence of alkali metal salts
The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin
Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria
The binding of cupric ions to bovine pancreatic ribonuclease studies with diligand metal-ion buffers
CALCIUM ION ACCUMULATION AND VOLUME CHANGES OF ISOLATED LIVER MITOCHONDRIA. REVERSAL OF CALCIUM ION-INDUCED SWELLING
Sugar transport in immature internodal tissue of sugarcane: I. Mechanism and kinetics of accumulation
Proton permeability and the regulation of potassium permeability in mitochondria by uncoupling agents
The role of Mg2+ in the regulation of the structural and functional steady-states in rat liver mitochondria
The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism
The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues
Bay K 8644, modifier of calcium transport and energy metabolism in rat heart mitochondria: a new intracellular site of action
Effects of cadmium in freshwater clams. II. Ultrastructural changes in the renal system ofAnodonta cygnea
Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria
Mg2+ restores membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphate movements
Induction of electroneutral exchanges of H+ with Na+, divalent and organic cations in rat liver mitochondria
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling
Hereditary polymyopathy and cardiomyopathy in the Syrian hamster. II. Development of heart necrotic changes in relation to defective mitochondrial function
Temporal profiles of accumulation of amyloid beta/A4 protein precursor in the gerbil after graded ischemic stress
Effects of propentofylline on hypoxia-hypoglycemia-induced calcium accumulation in gerbil hippocampal slices
Neurophysiological recovery after hypoglycemic coma in the rat: correlation with cerebral metabolism
Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study
Hypoglycemic brain injury: metabolic and structural findings in rat cerebellar cortex during profound insulin-induced hypoglycemia and in the recovery period following glucose administration
Ischemic Postconditioning Reduces NMDA Receptor Currents Through the Opening of the Mitochondrial Permeability Transition Pore and KATP Channel in Mouse Neurons
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