The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning

Molecular Reproduction and Development
Vidya K Nagalakshmi, Jing Yu

Abstract

The mammalian metanephric kidney is composed of two epithelial components, the collecting duct system and the nephron epithelium, that differentiate from two different tissues -the ureteric bud epithelium and the nephron progenitors, respectively-of intermediate mesoderm origin. The collecting duct system is generated through reiterative ureteric bud branching morphogenesis, whereas the nephron epithelium is formed in a process termed nephrogenesis, which is initiated with the mesenchymal-epithelial transition of the nephron progenitors. Ureteric bud branching morphogenesis is regulated by nephron progenitors, and in return, the ureteric bud epithelium regulates nephrogenesis. The metanephric kidney is physiologically divided along the corticomedullary axis into subcompartments that are enriched with specific segments of these two epithelial structures. Here, we provide an overview of the major molecular and cellular processes underlying the morphogenesis and patterning of the ureteric bud epithelium and its roles in the cortico-medullary patterning of the metanephric kidney.

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Citations

Jan 14, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maiko IkezawaHiroshi Yorifuji
Jul 28, 2016·World Journal of Nephrology·Michelle H T TaGopala K Rangan
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Jan 27, 2020·Cellular Signalling·Harini RamalingamVishal Patel

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