PMID: 20650162Dec 1, 1995Paper

The urgent need for in vitro tests in ecotoxicology

Toxicology in Vitro : an International Journal Published in Association with BIBRA
B Isomaa, H Lilius

Abstract

Ecotoxicological risk assessment should be regarded as consisting of several elements including molecular biology, cell toxicology, toxicology, ecology, chemistry and computer modelling [including quantitative structure-activity relationship (QSAR) considerations]. A successful risk assessment requires an approach that integrates data and knowledge from all the separate elements. The relative importance of a certain element will vary, depending on the situation or the chemical in question. One important, perhaps the most important, piece of information needed in risk assessment is the information about the concentration range at which a chemical exerts adverse effects on the organisms living in the aquatic environment. Without such information no prediction can be made or safety factors established. A combination of good in vitro tests could provide that information. A proper choice of endpoints in in vitro testing could also provide information on sublethal effects and toxic mechanisms involved, enabling even a more efficient approach than whole animal testing. For aquatic in vitro toxicology to progress further, there is a need for a more integrated, a more comparative and a more mechanistic approach and for large-scale evalu...Continue Reading

References

Jan 1, 1983·Annals of the New York Academy of Sciences·B Ekwall

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Citations

May 28, 2009·Environmental Science and Pollution Research International·Joanne Rodríguez PérezAmadeu M V M Soares
Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Balls
Apr 17, 2004·Ecotoxicology and Environmental Safety·Jiangning ChenZichun Hua
Dec 5, 1998·Chemosphere·M CamatiniC Urani
Dec 5, 1998·Chemosphere·C UraniM Camatini
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G RepettoM Repetto
Mar 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M SandbackaB Isomaa
Aug 6, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E-M FröjdöB Isomaa
Feb 22, 2016·The Science of the Total Environment·Dimitris VlastosIoannis Konstantinou
Mar 27, 1998·Ecotoxicology and Environmental Safety·M T Cronin, T W Schultz
May 9, 2002·Chemosphere·Julie R SewardT Wayne Schultz
Jul 17, 2018·Environmental Sciences Europe·Kristina RehbergerHelmut Segner
Jan 18, 2005·Alternatives to Laboratory Animals : ATLA·Helmut Segner

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