The urinary inflammatory profile in gluten free diet-adherent adolescents with type 1 diabetes and celiac disease

Journal of Diabetes and Its Complications
Emilia N De MeloFarid H Mahmud

Abstract

Our objective was to characterize urinary cytokine/chemokine excretion in adolescents with type 1 diabetes (T1D) and celiac disease (CD) adhering to gluten free diet (GFD) compared to matched T1D patients and healthy control (HC) group from an existing cohort. Eighteen T1D+CD+GFD patients aged 10-16years were identified and matched 2:1 for age, sex, diabetes duration and glycated hemoglobin to 36 T1D subjects and 36 HC. T1D+CD+GFD patients were adherent with a GFD. Urine and serum levels of cytokines/chemokines as well as baseline clinical and laboratory variables were assessed. T1D+CD+GFD patients exhibited lower levels of urinary IL-1B, IL-4, IL-5 (p<0.05) and IFN-γ, IL-8 and G-CSF levels (p<0.07) compared with T1D patients. Urinary biomarker levels between T1D+CD+GFD and HC were mostly similar. In contrast, urinary FGF-2, Flt-3, IL-1B, IL-1RA, IL-4, IL-5, IL-9, IL-10, IL-12p40, IL-15, MIP-1β, and TNF-β (p<0.05) were higher in T1D patients compared to HC. Similar levels of inflammatory markers were seen in the serum for all 3 groups. T1D+CD+GFD patients demonstrated decreased urinary inflammatory cytokine/chemokines compared to T1D and some similar to HC, which is suggestive of a potential modulatory role of treated CD on uri...Continue Reading

References

Mar 29, 2001·Diabetologia·R SinghL Beilin
Jul 12, 2002·Diabetes/metabolism Research and Reviews·Feng ZhengHelen Vlassara
Jul 29, 2004·Journal of the American Dietetic Association·Teresia GoldbergHelen Vlassara
Dec 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fiona Y ChowGregory H Tesch
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Pawel P WolkowAndrzej S Krolewski
Dec 17, 2008·Journal of Proteome Research·Ivano BertiniLeonardo Tenori
Feb 17, 2009·Diabetologia·V MalalasekeraM C Thomas
Sep 9, 2009·Human Immunology·John Sanil ManavalanGovind Bhagat
May 4, 2011·Nature Reviews. Nephrology·Juan F Navarro-GonzálezJavier García-Pérez
Jan 10, 2012·Annual Review of Food Science and Technology·Jan A DelcourBert Lagrain
Mar 16, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·D Z I CherneyH N Reich
Apr 27, 2012·Journal of Lipids·Gianna FerrettiAntonio Di Sario
May 19, 2012·Nutrients·Gianna FerrettiLetizia Saturni
Nov 14, 2012·BMC Gastroenterology·Greetje J TackMarco W J Schreurs
May 25, 2013·Journal of Internal Medicine·K MollazadeganJ F Ludvigsson
Jun 5, 2013·Alimentary Pharmacology & Therapeutics·S De MarchiE Arosio
Oct 15, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A Pham-ShortM E Craig
Mar 26, 2014·Diabetologia·Kaziwe MollazadeganJonas F Ludvigsson
Feb 19, 2015·Diabetes Care·Tilman R RohrerUNKNOWN DPV Initiative and the German BMBF Competence Network Diabetes Mellitus
Mar 26, 2015·Kidney International·Christina PapistaRenato C Monteiro

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Citations

Jan 10, 2017·Nutrition & Diabetes·J G Nunes-SilvaM S Queiroz

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