The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility

Biological Chemistry
L Kjøller

Abstract

Cell migration is a complex process requiring tight control of several mechanisms including dynamic reorganization of the actin cytoskeleton and adhesion to the extracellular matrix. The GPI-anchored urokinase plasminogen activator receptor (uPAR) has an important role in the regulation of cell motility in many cell types. This is partly due to the localization of proteolytic activity on the cell surface by binding of the serine protease uPA. Results accumulated over the last decade suggest that uPAR is also involved in motility control through other mechanisms. These include induction of signal transduction events after ligation with uPA, binding to the extracellular matrix molecule vitronectin (VN), and association with integrins and other transmembrane partners. In this review these mechanisms will be discussed with a special emphasis on how the GPI-linked receptor transmits signals to the intracellular milieu and how uPAR participates in the regulation of actin cytoskeleton reorganization and cell adhesion during cell migration.

References

Mar 11, 1991·The Journal of Clinical Investigation·A R Nusrat, H A Chapman
Mar 1, 1990·The Journal of Investigative Dermatology·M Del RossoE Panconesi
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M P StoppelliR K Assoian
Sep 30, 1987·Biochemical and Biophysical Research Communications·P W Gudewicz, N Gilboa
Apr 1, 1995·The American Journal of Physiology·N WangG Barlovatz-Meimon
Jan 29, 1993·Biochemical and Biophysical Research Communications·M Del RossoM Ruggiero
Sep 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H T MyöhänenA Vaheri
Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Feb 9, 1996·Cell·T J Mitchison, L P Cramer
Feb 1, 1996·The Journal of Clinical Investigation·M DewerchinD Collen
May 1, 1996·Experimental Cell Research·S M KanseK T Preissner
Apr 15, 1996·The Journal of Clinical Investigation·R G SitrinM R Gyetko
Sep 13, 1996·Science·Y WeiH A Chapman
Mar 28, 1997·International Journal of Cancer. Journal International Du Cancer·A Stahl, B M Mueller
Apr 21, 1997·The Journal of Cell Biology·R L KlemkeD A Cheresh
Jan 1, 1997·Annual Review of Immunology·T Taga, T Kishimoto
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·S M KanseK T Preissner
Feb 14, 1998·The Journal of Cell Biology·L A CaryJ L Guan
Feb 7, 1998·Science·A Hall

❮ Previous
Next ❯

Citations

Mar 30, 2004·Biochemical and Biophysical Research Communications·Nafisa DalviSimon A Whawell
Apr 23, 2009·The Journal of Biological Chemistry·Veera D'melloRaymond B Birge
Nov 4, 2005·Molecular Biology of the Cell·Roberta MazzieriFrancesco Blasi
Jan 7, 2005·Journal of Thrombosis and Haemostasis : JTH·H R Lijnen
May 29, 2004·Journal of Clinical Pathology·A NoelJ M Foidart
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher S GondiJasti S Rao
Apr 8, 2009·Thrombosis and Haemostasis·Allison A Eddy
Mar 14, 2008·Blood·Victoria StepanovaDouglas B Cines
Apr 18, 2008·BMC Bioinformatics·Bernard DegryseMaria Vittoria Cubellis
Oct 21, 2004·Biological Chemistry·Ulla MagdolenViktor Magdolen
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Guoqiang Zhang, Allison A Eddy
Dec 7, 2007·The Journal of Cell Biology·Valeria R CaiolfaNicolai Sidenius
Mar 5, 2003·The Journal of Cell Biology·Ralf-Peter CzekayDavid J Loskutoff
Mar 2, 2016·Bioconjugate Chemistry·Daniel M DupontJan K Jensen
Oct 2, 2009·Revista española de cardiología·Lina BadimónTeresa Padró
May 28, 2009·Journal of Cellular Physiology·Ralf-Peter Czekay, David J Loskutoff
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer
Feb 1, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Noelia LinoViviana Sánchez
Aug 15, 2006·Biochemical and Biophysical Research Communications·Man-Li TangSuet-Mien Tan
Oct 16, 2003·Biochemical and Biophysical Research Communications·Hamdi K Hamdi, Raquel Castellon
Dec 5, 2012·PloS One·Gemma PalazzoloMarcy Zenobi-Wong
Aug 12, 2008·Biochimica Et Biophysica Acta·Megumi IiizumiKounosuke Watabe
Nov 7, 2006·Trends in Biotechnology·Vinochani PillayPeter F M Choong
Apr 29, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·D TugcuG Aydogan
Nov 5, 2003·Medicinal Research Reviews·Charles Edo de Bock, Yao Wang
Apr 23, 2008·The Clinical Journal of Pain·Lars Arendt-Nielsen, Thomas Graven-Nielsen
Mar 17, 2007·The EMBO Journal·Jogender Singh Tushir, Crislyn D'Souza-Schorey
Sep 19, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lea M BeaulieuFrank C Church
Jun 13, 2008·Nature Reviews. Cancer·David R CroucherMarie Ranson
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Allison A Eddy, Agnes B Fogo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Related Papers

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
I TaskintunaW R Freeman
Journal of Bioenergetics and Biomembranes
W A Hendrickson
Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
M C Stacey, S D Mata
© 2022 Meta ULC. All rights reserved