The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy

Cancer Metastasis Reviews
Nicolai Sidenius, Francesco Blasi

Abstract

Cancer dissemination and metastasis is synonymous with invasive cell migration; a process in which the extracellular matrix (ECM) plays the dual role of the substratum on which the cells move as well as the physical obstacle that the cells have to surpass. To degrade the physical obstacle, which the ECM poses in the direction of migration, cells use proteolytic enzymes capable of degrading the ECM components. A major protease system responsible for ECM degradation is the plasminogen activation system, which generates the potent serine protease plasmin. The subject of this review, the urokinase-type plasminogen activator (uPA) and its receptor (uPAR), plays an impressive range of distinct, but overlapping functions in the process of cancer invasion and metastasis: Firstly, uPA/uPAR promotes extracellular proteolysis by regulating plasminogen activation. Secondly, uPA/uPAR regulates cell/ECM interactions as an adhesion receptor for vitronectin (Vn) and through its capacity to modulate integrin function. Thirdly, uPA/uPAR regulates cell migration as a signal transduction molecule and by its intrinsic chemotactic activity. This review is focused on recent insight into the cancer related biology of the uPA/uPAR system as well as its...Continue Reading

Citations

Mar 6, 2004·The Journal of Biological Chemistry·Bernard DegryseDavid J Loskutoff
May 27, 2004·Expert Review of Anticancer Therapy·Yong LiBarry J Allen
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Hiroshi KobayashiToshihiko Terao
Mar 18, 2005·Nature·Carla BoccaccioPaolo M Comoglio
Oct 13, 2005·Cancer Immunology, Immunotherapy : CII·Valeska HofmeisterJürgen C Becker
Nov 4, 2005·Molecular Biology of the Cell·Roberta MazzieriFrancesco Blasi
Jan 21, 2006·International Journal of Cancer. Journal International Du Cancer·Cornelis F M SierArko Gorter
Nov 1, 2006·Anti-cancer Drugs·Shinichi NozakiEtsuhide Yamamoto
Sep 29, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Farah Diba BegumClaus K Høgdall
Dec 12, 2007·Clinical & Experimental Metastasis·Chiara MarconiLido Calorini
Jun 6, 2007·The Journal of Cell Biology·Chris D MadsenNicolai Sidenius
Jun 2, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Federico FurlanFrancesco Blasi
Jul 25, 2008·Journal of Mammary Gland Biology and Neoplasia·Richard Marcotte, William J Muller
Feb 6, 2009·International Journal of Cancer. Journal International Du Cancer·Olivia C ProbstLukas Mach
Apr 23, 2009·The Journal of Biological Chemistry·Veera D'melloRaymond B Birge
Dec 25, 2008·International Journal of Cancer. Journal International Du Cancer·Edmund Kwok-Kwan TungIrene Oi-Lin Ng
Apr 21, 2010·Expert Opinion on Investigational Drugs·Ralf HildenbrandPhilipp Stroebel
May 25, 2010·Pathology Oncology Research : POR·Francois SaucyGian Dorta
Oct 26, 2010·Cellular and Molecular Life Sciences : CMLS·Nunzia MontuoriPia Ragno
Sep 22, 2011·Wiley Interdisciplinary Reviews. RNA·Kotb Abdelmohsen, Myriam Gorospe
Dec 14, 2011·Acta Oncologica·Filippo P D'AndreaAkmal Safwat
Oct 7, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R HughesG Jenkins
Jun 19, 2012·Cancer Biotherapy & Radiopharmaceuticals·Ying-Yu Ma, Hou-Quan Tao
Aug 9, 2013·International Journal of Peptide Research and Therapeutics·Agnieszka MarkowskaArkadiusz Surażyński
Nov 20, 2013·Virchows Archiv : an International Journal of Pathology·Sang Yun HaSeok-Hyung Kim
Apr 3, 2014·Biochemistry Research International·Najlah KochtebaneAghleb Bartegi
Sep 3, 2014·The Journal of Clinical Investigation·Mohit SachdevaDavid G Kirsch
Apr 15, 2015·Frontiers in Immunology·Malcolm Finlayson
Jan 8, 2016·Chinese Journal of Cancer·Peipei XingJilong Yang

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