The Urolift System for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A NICE Medical Technology Guidance

Applied Health Economics and Health Policy
Alistair RayGrace Carolan-Rees

Abstract

As part of its Medical Technologies Evaluation Programme (MTEP), the National Institute for Health and Care Excellence (NICE) invited Neotract (manufacturer) to submit clinical and economic evidence for their prostatic urethral lift device, Urolift, for the relief of lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS BPH). The Urolift System uses implants to retract the prostatic lobe away from the urethral lumen. The clinical evidence used in the manufacturer's submission shows that Urolift is effective for the treatment of BPH. Urolift delivers a weighted mean International Prostate Symptom Score (IPSS) improvement of between 9.22 and 11.82 points. These Urolift improvements are greater than a published 'marked improvement' in IPSS score of 8.80. Comparison with randomised controlled trials (RCTs) of TURP (Transurethral Resection of Prostate) and HoLEP (Holmium Laser Enucleation of Prostate) show that Urolift does not yield better clinical outcomes from baseline compared to TURP and HoLEP in terms of IPSS, QoL (Quality of Life) and Qmax (maximum urinary flow). However, Urolift appears to have the advantage in terms of minimal and mild complications, and this may be of interest to patients and urologi...Continue Reading

References

Jul 26, 2003·Transfusion Medicine·S J Varney, J F Guest
May 4, 2007·European Urology·Peter J GillingMark R Fraundorfer
Dec 24, 2011·Journal of Dairy Science·A-M HeikkiläS Pyörälä
Aug 28, 2012·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·N B DelongchampsM Peyromaure
Oct 15, 2013·The Journal of Sexual Medicine·Kevin T McVaryUNKNOWN L.I.F.T. Study Investigators
Dec 15, 2015·Lower Urinary Tract Symptoms·Tomonori YamanishiTomoyuki Uchiyama

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Citations

Jul 20, 2016·Current Urology Reports·Johnson F Tsui, Christopher M Dixon
Mar 9, 2017·Expert Review of Medical Devices·Anish PushkaranIqbal S Shergill
Jan 13, 2018·World Journal of Urology·Siska Van BruwaeneIgnace Billiet
Oct 5, 2017·Revista da Associação Médica Brasileira·Ricardo Luís Vita NunesDavi Souza Constantin
Jul 20, 2018·Current Urology Reports·Bradley C Gill, James C Ulchaker
May 26, 2017·BJU International·Peter J Gilling
Jun 14, 2020·Wiener klinische Wochenschrift·Rahat UllahXiaohui Zhou
Feb 23, 2019·Therapeutic Advances in Urology·Petros SountoulidesStavros Gravas

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Software Mentioned

Urolift
mTURP
BiTURP
HoLEP

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