The U.S.-Japan Cooperative Cancer Research Program: some highlights of seminars, interdisciplinary program area, 1981-1996

Japanese Journal of Cancer Research : Gann
R W Miller

Abstract

Thirty-one seminars have been held in the 16 years since 1981. A principal interest from the beginning was the genetics of cancer, well before this subject became widely popular. This interest arose in part because of marked binational differences in type-specific cancer rates, such as the very low rates among Japanese for Hodgkin's disease in the young, testicular cancer, Ewing's sarcoma, superficial spreading melanoma, chronic lymphocytic leukemia, and Wilms' tumor (half the U.S. frequency). Three seminars were devoted to the seeming reciprocal relationship between B-cell lymphoma (low in Japan) and certain autoimmune diseases (high in Japan), which is perhaps similar in origin to the male/female differences in the rates for these diseases. A seminar on Li-Fraumeni syndrome led to the recognition of cases among Japanese pedigrees brought to the meeting, and generated a study of its occurrence in Japanese families with adrenocortical carcinoma in a child. Another seminar revealed a marked clustering of rare cancers in Werner's (premature aging) syndrome in Japan, and led to a binational study and analysis of case-reports worldwide. Three seminars on pathology heightened appreciation of the importance of subclassifying cancer b...Continue Reading

References

Dec 1, 1979·American Journal of Diseases of Children·D T Purtilo, J L Sullivan
Dec 4, 1991·Journal of the National Cancer Institute·M H Greene
Aug 1, 1991·Japanese Journal of Cancer Research : Gann·Y TsunematsuM Ono
May 1, 1989·The Journal of Investigative Dermatology·J M Elwood
Dec 1, 1994·Pathology International·S Ikehara
May 1, 1994·Japanese Journal of Cancer Research : Gann·L Tomatis
Feb 24, 1994·Nature·R DollS C Darby

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Citations

Sep 1, 2007·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Mitsuyuki Abe
Mar 21, 1998·American Journal of Medical Genetics·R W Miller
Jul 3, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyoshi Kita

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