PMID: 9525302Apr 3, 1998Paper

The US Lung Health Study

Respirology : Official Journal of the Asian Pacific Society of Respirology
A S Buist

Abstract

The US Lung Health Study was a randomized clinical trial carried out in 10 clinical centres in the United States of America and Canada that enrolled 5887 male and female smokers age 35-60 years with early chronic obstructive pulmonary disease (COPD). Its purpose was to determine whether a programme incorporating smoking intervention and use of an inhaled bronchodilator (ipratropium bromide) can slow the rate of decline in the forced expiratory volume in one second (FEV1) in middle aged smokers with early COPD. Participants were randomized with equal probability into three groups: (i) smoking intervention plus bronchodilator; (ii) smoking intervention plus placebo; or (iii) no intervention. The primary outcome was rate of change and cumulative change in FEV1 over a 5 year period. The primary finding was that the use of the bronchodilator did not influence the long-term decline in FEV1. However, the aggressive smoking intervention programme significantly reduced the age-related decline in FEV1.

References

Jun 1, 1991·The American Review of Respiratory Disease·P L EnrightA S Buist
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·W M VollmerA S Buist

❮ Previous
Next ❯

Citations

Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·David M Mannino, Victor A Kiriz
Feb 24, 2001·Acta Anaesthesiologica Scandinavica·A M MøllerT Pedersen
Apr 14, 2000·Clinics in Chest Medicine·J M Sethi, C L Rochester
Dec 20, 2003·Chest Surgery Clinics of North America·Cesar A Keller
Nov 28, 2006·Revue des maladies respiratoires·I Tillie-LeblondUNKNOWN pour le groupe EXACO
Aug 23, 2016·The Cochrane Database of Systematic Reviews·Eva A M van EerdDaniel Kotz
Jun 14, 2003·The Cochrane Database of Systematic Reviews·R M van der MeerC P van Schayck
Sep 21, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·B Le FollUNKNOWN Working Group of AFSSAPS
Nov 15, 2000·Journal of Epidemiology and Community Health·A LanghammerL Bjermer
Dec 30, 2020·Expert Opinion on Pharmacotherapy·Sabina Antonela AntoniuAntigona Carmen Trofor
May 5, 2021·BMC Medical Research Methodology·Francesca GrazianoPaola Rebora
Sep 9, 2021·The Cochrane Database of Systematic Reviews·Sadia JanjuaMitchell Batavia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
J R HughesS A Heatley
© 2022 Meta ULC. All rights reserved