The Use and Misuse of ACE Inhibitors in Patients with Single Ventricle Physiology

Heart, Lung & Circulation
Thomas G WilsonYves d'Udekem

Abstract

There are no clear guidelines for the use of angiotensin-converting enzyme (ACE) inhibitors in patients with single ventricle physiology, especially after the Fontan procedure. Despite this, ACE inhibitors are widely prescribed within the single ventricle population. We decided to review the literature to better establish the efficacy of ACE inhibitors in the single ventricle population and summarise their indications. A review of the literature was conducted to identify relevant articles describing use of ACE inhibitors in single ventricle patients both before and after the Fontan procedure. A search in the Ovid MEDLINE and Embase databases identified a total of 140 articles, of which 31 were deemed relevant to the review. There is little published evidence supporting the use of ACE inhibitors in patients with single ventricle physiology. Based on the current literature, it is possible that ACE inhibitors are overprescribed in patients with single ventricle physiology. The coordination of large, prospective studies through initiatives such as the Australia and New Zealand Fontan Registry is necessary to guide the appropriate use of ACE inhibitors in the single ventricle population.

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Citations

Jul 19, 2018·Congenital Heart Disease·Doris P YimgangGeoffrey L Rosenthal
Dec 25, 2019·Heart Failure Reviews·Sumeet S Vaikunth, George K Lui
Feb 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anastacia M GarciaStephanie J Nakano
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Feb 8, 2019·European Journal of Heart Failure·Floris-Jan S RidderbosJoost P van Melle
Sep 21, 2018·Frontiers in Cardiovascular Medicine·Nischal R PandyaLuregn J Schlapbach
Jan 13, 2021·Cardiology in the Young·May Al-ShawkAmer Harky
Jul 24, 2021·Cardiology in the Young·Lars SøndergaardPaul Clift

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