Dec 15, 1979

The use of 125I-fibrinogen in the diagnosis of deep venous thrombosis in medical practice (author's transl)

Medicina clínica
A Escribá PoloD Espinós Pérez


A series of 38 "high risk" selected cases of deep venous thrombosis were studied in an internal Medicine Department. Fibrinogen-125I was used. Phlebographic verification was sought in those cases with a positive response to the fibrinogen. From the 38 cases 13 turned out to be positive; in 8 the venous thrombus was identify by venography. In two cases the dorsal venous arch could not be filled. In one case the phlebography could not be carried out. In the remaining two cases the venography did not show a thrombus but there was a pathologic fracture with hematoma and an ossifying myositis, respectively. Both cases were interpreted as false positives to the radioactive fibrinogen. One of them had suggestive clinical manifestations of deep venous thrombosis. Of the eight cases which were positive to the venography and radioactive fibrinogen only four showed a clinical picture suggestive of deep venous thrombosis. If the three cases with negative venographies are included only 36.3 percent of the patients had clinical manifestations. Among the 25 cases which were negative to the radioactive fibrinogen none of them had a clinical picture of deep venous thrombosis, although in 64 percent of them at least one of the clinical signs col...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Pathological Fracture
Venous Thrombosis
Iodine Radioisotopes
Phlegmasia Alba Dolens
Venography - Procedure

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.