The use of 17 alpha-hydroxyprogesterone caproate (17p) in women with cervical cerclage

American Journal of Perinatology
Andrei RebarberDaniel H Saltzman

Abstract

Our objective was to compare the incidence of recurrent spontaneous preterm delivery (SPTD) in patients with cervical cerclage treated with weekly 17 alpha-hydroxyprogesterone caproate (17P) injections versus daily outpatient nursing surveillance (ONS) without 17P. Included in this retrospective cohort study were singleton gestations with cerclage placed at the discretion of the provider due to prior SPTD, delivering between January 1, 2004 and May 1, 2006. The study group (n = 232) consisted of women receiving once-weekly nursing visit and 17P injection. The control group (n = 1650) consisted of women enrolled for ONS (twice-daily electronic uterine contraction monitoring and nursing assessment). Data were further stratified by the number of prior preterm deliveries (1, > 1). Primary study outcome was the incidence of SPTD. No difference in rates of recurrent SPTD at < 37 or < 35 weeks were observed between the study and control groups. Study patients were less likely to be diagnosed with preterm labor (PTL) than controls (45.7% versus 70.8%, respectively; P < 0.001). The incidence of preterm premature rupture of membranes was similar between the groups (8.6% versus 8.1%; P = 0.770). We concluded that the incidence of recurren...Continue Reading

Citations

Apr 23, 2013·Obstetrics and Gynecology International·Emily A DefrancoLouis J Muglia
Oct 22, 2008·Taiwanese Journal of Obstetrics & Gynecology·An-Shine ChaoPeter Ching-Chang Hsieh
Sep 29, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Mohammad Ahmed MaherMohamed Fayez Bazeed
Mar 31, 2010·American Journal of Obstetrics and Gynecology·Vincenzo BerghellaUNKNOWN Vaginal Ultrasound Trial Consortium
May 31, 2011·American Journal of Obstetrics and Gynecology·Steve N CaritisUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Oct 26, 2016·Obstetrics and Gynecology·Bethany StetsonHeidi Leftwich
Jan 26, 2017·Obstetrics and Gynecology·Vincenzo BerghellaJeff M Szychowski
Jan 11, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rachel G SinkeyAnthony O Odibo
Oct 20, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Ahizechukwu C EkeErnest M Graham
Jan 11, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Katie E LichterAhizechukwu C Eke
Apr 5, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mohammed K AliAhmed M Abbas
May 18, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Patrik ŠimjákJiří Sláma
Mar 15, 2016·Clinical Obstetrics and Gynecology·S Lindsay Wood, John Owen
Sep 20, 2016·The Journal of Obstetrics and Gynaecology Research·Eun Young JungJung Kyung Joo
Sep 3, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Azin AlaviShahram Zare

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