The use of 3'-deoxy-3'-18 F-fluorothymidine (FLT) PET in the assessment of long-term survival in breast cancer patients treated with neoadjuvant chemotherapy

Annals of Nuclear Medicine
Benjamin E UeberrothAnthony F Shields

Abstract

To assess the role of serial FLT-PET scans during early neoadjuvant treatment as a prognostic marker of response to treatment and survival. This study is a prospective cohort study which draws from a larger original study which examined the utility of FLT-PET imaging across multiple cancers. Our cohort consisted of patients who had biopsy-confirmed breast cancer amenable to surgical resection. These patients underwent serial FLT-PET scans: the first scan prior to starting neoadjuvant chemotherapy (NAC), and a second scan shortly after starting NAC. SUVmean was derived using an isocontour ROI drawn approximately half way between the SUVmax and background on three planes for each scan. The change in mean standardized uptake value (SUVmean) for the primary tumor between these two scans was then calculated, and patients were stratified into "responder" and "non-responder" groups based on a cut-off of 20% arithmetic decrease in SUVmean between the two scans. The rates of pathologic complete response (pCR) on subsequent surgical excision, overall survival (OS), and progression-free survival (PFS) were then compared between the two groups to assess for significant difference between responders and non-responders. 16 patients (n = 16) ...Continue Reading

References

Jul 2, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Anthony F ShieldsOtto Muzik
Nov 1, 2011·Breast Cancer Research and Treatment·Hélène Kolesnikov-GauthierJacques Bonneterre
Jun 12, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Farrokh DehdashtiBarry A Siegel
Jul 24, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Selin CarkaciWei T Yang
Jun 3, 2014·Surgical Oncology Clinics of North America·Mediget Teshome, Kelly K Hunt
Jul 19, 2014·The Breast : Official Journal of the European Society of Mastology·Michael UntchGunter von Minckwitz
Mar 3, 2015·Annals of Surgical Oncology·Patricia Cortazar, Charles E Geyer
Apr 23, 2015·Annals of Nuclear Medicine·Eliot T McKinleyH Charles Manning
Jul 15, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Laurence ChampionMyriam Wartski
Sep 12, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lale KostakogluUNKNOWN ACRIN 668 Investigative Team

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Citations

Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Keke LiangCaius G Radu
Jan 14, 2022·Nuclear Medicine Communications·Luca UrsoMirco Bartolomei

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