The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile

AAPS PharmSciTech
Adil AjmalJukka Rantanen

Abstract

Development of new product design principles is crucial for obtaining pharmaceutical products with controlled functionality. Four different molds were designed using a computer-aided design (CAD) software and 3D printed with polylactic acid (PLA). A hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG)-based formulation containing indomethacin as the active pharmaceutical ingredient (API) was casted into the molds. Each mold produced a tablet that was designed to disintegrate into a defined number of sections (2, 4, and 6). This was achieved by incorporating break lines (regions that were significantly thinner than the remainder of the tablet) to control the disintegration process. Disintegration and drug release from these designed tablets was contrasted with a casted tablet without break lines. Disintegration studies confirmed that the casted tablets disintegrated according to their design. Drug-release studies meanwhile demonstrated that tablets with a greater number of sections released the API at a faster rate than those with fewer sections; for example, the 6-sectioned tablet released the API at twice the rate of the tablet without any break lines. It is expected that by using this concept, it would be possib...Continue Reading

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Citations

Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan

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Methods Mentioned

BETA
differential scanning calorimetry

Software Mentioned

Cura

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