The use of a 532-nm laser fitted with a balloon and a cylindrical light diffuser to treat benign biliary stricture: a pilot study.

Lasers in Medical Science
Jin-Seok ParkHyun Wook Kang

Abstract

Endoscopic management of benign biliary stricture (BBS) remains challenging. Stenting is currently used for BBS management, but refractory BBS remains problematic. The aim of this study was to assess the safety and feasibility of a dilation balloon-equipped cylindrical light diffuser for BBS in a large animal model. A total of seven mini-pigs were used in the current study. Laser settings were chosen based on the findings of a previous animal study. Five animals were used in a preliminary study to establish process conditions. BBSs were created in the common bile ducts of the other two animals by intraductal radiofrequency ablation (RFA) via endoscopic retrograde cholangiography (ERC). At 4 weeks post-RFA, laser ablation was performed using a customized balloon-equipped cylindrical diffuser at 10 W for 10 s while maintaining balloon inflation for 10 s at 5 atm. A follow-up ERC was performed at 4 weeks post-laser ablation and the animals were sacrificed for histologic evaluation. BBS was observed in all animals by ERC at 4 weeks post-RFA. The mean bile duct stricture diameter in the two animals as determined by ERC was 0.8 mm. Laser ablations were performed without technical difficulty and no adverse event was encountered. At 4 ...Continue Reading

References

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May 8, 2014·Gastroenterology·Jacques DevièreUNKNOWN Benign Biliary Stenoses Working Group
Aug 12, 2016·Journal of Korean Medical Science·Jin Seok ParkDon Haeng Lee

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Citations

May 10, 2020·Clinical Endoscopy·Purnima Bhat, Lars Aabakken
Mar 25, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Seok JeongDon Haeng Lee

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