The use of a combination of pentoxifylline and tocopherol in women with a thin endometrium undergoing assisted conception therapies--a report of 20 cases

Human Fertility : Journal of the British Fertility Society
Santanu AcharyaAdam H Balen

Abstract

An optimal thickness of the endometrium is considered to be one of the prerequisites for successful implantation of the embryo. A retrospective analysis was carried out to investigate the use of Pentoxyfylline and tocopherol in improving the endometrial thickness in cases that are unresponsive to conventional therapy. Twenty women with thin endometrium (<6 mm) undergoing either ovulation induction or frozen embryo transfer cycles were prescribed 800 mg of PTX and 1000 IU of Vit E daily. In 11 cases, the etiology for thin endometrium was unknown. The known causes included Turners' syndrome (3), Kallman's syndrome (1), idiopathic hypogonadotrophic hypogonadism (2), premature ovarian failure (1) and Asherman's syndrome (2), none of which had responded to conventional hormonal stimulation. The mean duration of treatment was 8.1 months (+/-4.5, range 1-18 months). The mean thickness of endometrium before and after treatment was 4.37 mm (+/-1.5 mm) and 6.05 mm (+/-1.83 mm), respectively (p = 0.001, 95% CI 0.84-2.5). Overall, 14 (73.7%) women showed improvement in endometrial thickness which was the primary outcome. Pregnancy occurred in eight women (40%) of which three were natural, one had ovulation induction and another five had fr...Continue Reading

References

Jan 20, 1998·Molecular Human Reproduction·T MaruyamaJ Yodoi
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S DelanianJ L Lefaix
Jun 12, 2002·Fertility and Sterility·Hélène Letur-KönirschSylvie Delanian
Mar 1, 1991·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Y GonenH Abramovici

❮ Previous
Next ❯

Citations

Apr 4, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Oshrit Lebovitz, Raoul Orvieto
Mar 8, 2016·Reproductive Biomedicine Online·Juan A Garcia-VelascoLuis Rodriguez-Tabernero
May 10, 2011·Reproductive Biomedicine Online·Charles M March
Apr 26, 2016·Journal of Human Reproductive Sciences·Nalini Mahajan, S Sharma
Jul 15, 2015·Medical Hypotheses·Arsalan AzimiMohammad Mahdi Sagheb
Mar 22, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fábio Cruz, José Bellver
Aug 29, 2014·BioMed Research International·Wan Tinn TehMartha Hickey
Apr 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rashmi Kudesia, Satu Kuokkanen
Oct 14, 2014·The Cochrane Database of Systematic Reviews·Rosa B Gutarra-VilchezXavier Bonfill Cosp
Apr 1, 2016·Journal of Gynecologic Oncology·So-Youn KimTeresa K Woodruff
Oct 13, 2018·The Cochrane Database of Systematic Reviews·Rosa B Gutarra-VilchezMaria José Martinez-Zapata
Sep 11, 2019·Journal of Assisted Reproduction and Genetics·Noemie RanisavljevicCharlotte Sonigo
Aug 30, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Zahra HashemiZatollah Asemi
Aug 30, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ruochun LianSu Liu
Aug 25, 2018·BioMed Research International·Michał CiebieraMarta Włodarczyk
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
Sep 17, 2020·Reproductive Sciences·Jitender Kumar BhardwajPriyanka Saraf
Oct 20, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Candan EkerTuba Gunel
Mar 3, 2021·Cell and Tissue Research·Neda KeyhanvarRalf Dittrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.