The use of a compact protable microcomputer system (EPSON HX 20) to measure on-line the contractile activity of the digestive tract from eight channels. Application to pharmacological tests

Journal of Pharmacological Methods
T HachetC Rode

Abstract

The chronically prepared gut with strain-gauge transducers is a useful model to evaluate the effects of drugs affecting the digestive motility in fed and fasted animals. This paper describes a rapid and reproducible on-line microcomputerized technique to evaluate continuously, 23 hr per day, the level of gut motility using a portable compact microcomputer (EPSON HX 20). The gastric, intestinal, and colonic motility indexes were automatically determined from the surface of the contractile waves from eight different sites over periods of time varying from 1 to 120 min. This system has been successfully used to investigate the motor effects of spasmolytic or antidiarrheal drugs inravenously (N-butyl-hyoscine, trospium, secoverine, and prifinium) or orally (trimebutine, loperamide) administered in conscious, fed dogs.

References

Jul 1, 1975·The Journal of Physiology·L BuenoY Ruckebusch
Dec 1, 1978·Japanese Journal of Pharmacology·O YagasakiY Sohji
Sep 1, 1980·International Journal of Bio-medical Computing·A Latour, L Bueno
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·J FioramontiL Bueno
Mar 1, 1983·Digestive Diseases and Sciences·J Fioramonti, L Bueno
Mar 1, 1984·Digestive Diseases and Sciences·I Altaparmakov, M Wienbeck
Sep 1, 1981·Journal of Pharmacological Methods·L BuenoX Pascaud

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Citations

Sep 1, 1989·Medical & Biological Engineering & Computing·W J De RidderJ A Schuurkes
Mar 25, 2008·Therapeutics and Clinical Risk Management·David Rp Guay
Aug 1, 1996·Canadian Journal of Physiology and Pharmacology·A KrantisF Johnson

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