The use of a retroviral vector to identify foetal striatal neurones transplanted into the adult striatum

Experimental Brain Research
P C EmsonC J Wilson

Abstract

A retrovirus which encodes beta-galactosidase was used to infect embryonic rat striatal cells before grafting these cells into the lesioned adult rat striatum. Examination of the grafts after long term survival (8 months) revealed that a few small and large cells expressed large amounts of bacterial beta-galactosidase activity. The larger diameter cells were identified as neurones by their size, shape and presence of neuronal processes. The identity of the small diameter cell types was not established.

References

Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D HuszarA Bernstein
Jan 1, 1989·Trends in Neurosciences·J R Sanes
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J PriceC Cepko
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G E GrayJ R Sanes

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Citations

Dec 1, 1992·Brain Research. Molecular Brain Research·W S RosenbergO Isacson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B E WojcikM Peschanski

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