The use of abciximab in the treatment of acute cerebral thromboembolic events during neuroendovascular procedures

Surgical Neurology
Gregory J VelatRobert A Mericle

Abstract

Recently, a great interest has emerged regarding the use of abciximab for treatment of stroke. Thromboembolic events that occur during neuroendovascular procedures represent a unique subset of stroke patients because definitive angiographic diagnosis and treatment can be performed immediately. The existing literature on this situation suggests excellent results; however, most publications are case reports, and the largest series is 13 cases. We report our experience using abciximab in the treatment of acute thromboembolic events that occur during neuroendovascular procedures. We reviewed the last 1373 consecutive patients who underwent neuroendovascular procedures at the University of Florida from our prospectively maintained clinical database. Of these patients, 29 (2.11%) endovascular cases were complicated by acute cerebral thromboembolic events that were treated with abciximab. Abciximab was administered in less than 1 hour after the onset of the occlusion in every patient. The Thrombolysis In Myocardial Infarction (TIMI) scale was used to measure immediate angiographic outcome, and the Modified Rankin Scale (MRS) was used to measure clinical outcome at the time of follow-up. Independent outcome was defined as an MRS of 3 o...Continue Reading

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Citations

Dec 17, 2009·Neurological Research·Ronen R LekerJosé E Cohen
Sep 24, 2009·The Indian Journal of Radiology & Imaging·Santhosh Joseph, Ravindra Kamble
Jul 29, 2009·Klinische Neuroradiologie·Jens Fiehler, Thorsten Ries
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Nov 26, 2010·Neurosurgery·Mohamed AggourJean-Pierre Graftieaux
Mar 17, 2007·Current Cardiology Reports·Chirag D GandhiAman B Patel

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