The use of agomelatine in OCD: effects on the motivational aspects and dysregulated circadian rhythms

Expert Opinion on Investigational Drugs
Giulio PerugiNunzio Bucci

Abstract

A considerable proportion of subjects with obsessive-compulsive disorder (OCD) have shown resistance or an incomplete response to the standard first-line treatment of serotonin reuptake inhibitors. In particular, patients often continue to show disrupted circadian rhythms with related sleep disturbances and comorbidity with bipolar spectrum disorders. This paper discusses the possible role of agomelatine in the treatment of motivational aspects and dysregulated circadian rhythms of OCD. In particular, the article highlights the pharmacokinetics and pharmacodynamics of agomelatine. Additionally, the article highlights its clinical efficacy, safety and tolerability and provides perspectives on its future development as a potential therapy for the treatment of OCD. Agomelatine offers the effective resynchronization of circadian rhythm with an improvement in patients' reward mechanism, incentive motivation and general OCD symptoms. Indeed, the authors believe that agomelatine could be a valid alternative drug in treatment-resistant OCD patients, particularly those suffering with bipolar spectrum comorbidity and related sleep disturbances.

References

Dec 1, 1982·Archives of General Psychiatry·T R InselD L Murphy
Dec 1, 1981·The American Journal of Psychiatry·J RapoportW Mendelson
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·L A Valleni-BasileS P Cuffe
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·F HohagenM Berger
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·S M ArmstrongJ R Redman
Nov 29, 1995·Psychiatry Research·Y W Chen, S C Dilsaver
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·L MartinetE Mocaer
Apr 1, 1997·The American Journal of Physiology·L GarciaP Sartor
Feb 6, 1999·Journal of Clinical Psychopharmacology·R C RosenM Menza
Aug 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H P LandoltA A Borbély
Apr 18, 2000·Archives of General Psychiatry·G NestadtR Hoehn-Saric
Jul 24, 2002·The International Journal of Neuropsychopharmacology·Stefano PallantiUNKNOWN International Treatment Refractory OCD Consortium
Jun 5, 2003·Journal of Affective Disorders·E G HantoucheH S Akiskal
Jan 16, 2004·The New England Journal of Medicine·Michael A Jenike
Mar 31, 2005·Seminars in Neurology·Jeffrey S Durmer, David F Dinges
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jun 14, 2005·Archiv der Pharmazie·Darius P Zlotos
Jul 12, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nicholas BardenElisabeth Mocaër
Aug 4, 2005·Journal of Biological Rhythms·Derk-Jan Dijk, Malcolm von Schantz
Oct 1, 2005·International Review of Psychiatry·George N Papadimitriou, Paul Linkowski
Oct 27, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S H Kennedy, R Emsley
Nov 22, 2005·Pain·Monika Haack, Janet M Mullington
Feb 28, 2006·Biological Psychiatry·Mounira BanasrAnnie Daszuta
Apr 21, 2006·Human Psychopharmacology·Franca CentorrinoRoss J Baldessarini
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Oct 7, 2006·Annals of Clinical Biochemistry·Debra J Skene, Josephine Arendt
Oct 20, 2006·Journal of Psychiatric Research·Michael KlugeAxel Steiger
Dec 5, 2006·CNS Drugs·Michael Zupancic, Christian Guilleminault
Dec 7, 2006·European Archives of Psychiatry and Clinical Neuroscience·Ulrich VoderholzerFritz Hohagen
Feb 24, 2007·Psychiatry Research·Michael KlugeAxel Steiger
May 9, 2007·Archives of General Psychiatry·Kathleen R MerikangasRonald C Kessler
Sep 12, 2007·Bipolar Disorders·Joseph R CalabreseUNKNOWN Agomelatine Bipolar Study Group
Nov 9, 2007·European Archives of Psychiatry and Clinical Neuroscience·Ulrich HegerlOliver Pogarell
Jul 30, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Palmiero Monteleone, Mario Maj

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Citations

Jul 29, 2015·Current Psychiatry Reports·Meredith E ColesJacob A Nota
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman

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