The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment

Artificial Organs
Tatsuya KinJonathan R T Lakey

Abstract

The aim of this study was to investigate whether the use of a medically approved biodegradable scaffold as a solid support system would enhance graft survival following transplantation into the omental pouch in a preclinical large animal model. Six beagle dogs underwent total pancreatectomy followed by islet autotransplantation into the omental pouch. Four dogs received islets seeded in a biodegradable polymer scaffold and two received free islets without a scaffold. All four animals that received islets in the scaffold became normoglycemic without exogeneous insulin injection. One dog, transplanted with the largest number of islets, maintained a normal metabolic state until the graft was removed at 5 months posttransplant. In two out of the three that received a marginal islet mass, insulin independence was sustained up to 2 months. In contrast, two dogs transplanted with a similar marginal mass without the scaffold never became normoglycemic. Histological examination of the grafts in the scaffold showed numerous well-granulated, insulin-containing cells as well as glucagon-positive cells. These results indicate that biodegradable scaffolds may enhance survival and function of islet grafts. Manipulation of the microenvironment...Continue Reading

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Citations

Jul 13, 2011·Current Diabetes Reports·Danielle J Borg, Ezio Bonifacio
Jul 27, 2011·Current Diabetes Reports·Elisa Cantarelli, Lorenzo Piemonti
Feb 28, 2009·Artificial Organs·Paul S Malchesky
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Aug 25, 2017·Scientific Reports·Katarzyna SkrzypekDimitrios Stamatialis
Jul 25, 2021·Polymers·Yesenia Sánchez-CardonaNatalia Moreno-Castellanos
Nov 5, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Freya Van HulleDaniel Jacobs-Tulleneers-Thevissen

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