PMID: 2501765Jun 1, 1989Paper

The use of an insulin bolus in low-dose insulin infusion for pediatric diabetic ketoacidosis

Pediatric Emergency Care
R Lindsay, R G Bolte

Abstract

The use of an initial bolus of insulin prior to the initiation of low-dose insulin infusion therapy was evaluated in 56 episodes of diabetic ketoacidosis (DKA) in 38 children. The cases were randomly assigned to a group that received a bolus of insulin (n = 24) and to a group that did not (n = 32). After the first hour of insulin therapy, the decline in serum glucose level and the changes in serum osmolality were statistically similar in the two groups, regardless of the degree of acidosis. The time required to reach a serum glucose level of less than 250 mg/dl and the total duration of insulin infusion likewise were similar in the two groups. The use of a bolus of insulin at the onset of treatment for DKA appears unnecessary.

Citations

Jun 28, 2007·Indian Journal of Pediatrics·R R JahagirdarS K Lalwani
May 23, 2007·American Journal of Therapeutics·Paul Bradley, Joseph D Tobias
Jan 8, 2009·American Journal of Therapeutics·Paul Bradley, Joseph D Tobias
Jan 23, 2004·Archives of Disease in Childhood·D B DungerUNKNOWN LWPES
Dec 4, 2010·Indian Journal of Pediatrics·Sindhu SivanandanRakesh Lodha
Aug 7, 2013·Emergency Medicine Clinics of North America·Laura Olivieri, Rose Chasm
May 16, 2014·Canadian Journal of Diabetes·Diane WherrettDanièle Pacaud
May 16, 2014·Canadian Journal of Diabetes·Jeannette GoguenJeremy Gilbert
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May 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·D K Macintire
Mar 8, 2007·Pediatric Diabetes·Joseph WolfsdorfUNKNOWN International Society for Pediatric and Adolescent Diabetes
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Jun 12, 2021·Canadian Journal of Diabetes·Zoyah ThawerDavid Seleman Saleh

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