The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Giuseppe BifulcoCarmine Nappi

Abstract

To investigate the impact of a 3 months preoperative administration of an oral contraceptive, containing dienogest (DNG) and estradiol valerate (E₂V) on the outcome of office operative hysteroscopy (OOH). One-hundred and forty-two patients diagnosed at office hysteroscopy as having an asynchronous endometrium associated with either a broad-base sessile endometrial polyp (>1.5, <2.5 cm) or a uterine septum (>1/3 uterine cavity) or scheduled for tubal sterilization were enrolled into a prospective case-control study at University "Federico II" of Naples. 86/142 patients accepted the preoperative hormonal treatment (Group A), while 56/142 refused, thus becoming controls (Group B). Group A underwent OOH during the 10th-20th days of the third cycle of treatment. In Group B OOH was performed at enrolment, together with the diagnostic procedure. The study outcomes were: endometrial pattern, success rate, operating time, degree of surgical difficulty and pain score. An overall improvement of the endometrium was reported in 100% of cases in Group A. A statistically significant difference in success rate could not be demonstrated between two groups. Operative procedures were performed significantly quicker and easier in Group A than Grou...Continue Reading

References

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Citations

Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·X DeffieuxF Pierre
Dec 24, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P CarabiasE Genover-Llimona
Jan 9, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio Simone LaganàVittorio Italo Palmara
Mar 17, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ai-Zhen LiuBao-Zhi Guo
May 20, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xavier DeffieuxFabrice Pierre
Dec 3, 2016·Archives of Gynecology and Obstetrics·Antonio Simone LaganàAndrea Romano

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