PMID: 19141899Jan 15, 2009Paper

The use of androgen loaded tcpl delivery devices to assess the proinflammatory cytokines profiles

Biomedical Sciences Instrumentation
Ham Benghuzzi, Michelle Tucci

Abstract

The goal of this study is to investigate the pathophysiological changes, of both local and systemic control factors (cytokines and structural alterations), associated with continuous and sustained delivery of T and DHT using tricalcium-phosphate-lysine (TCPL) delivery devices. A total of 32 adult male Sprague Dawley rats were equally divided into four equal groups. Animals in group 1 were left untreated and served as intact control. Animals in group 2 were implanted with an empty ("sham") drug delivery device, and animals in groups 3 and 4 were implanted with a drug delivery carrier containing either DHT or T, respectively. Animal weights were recorded weekly and blood was collected bi-weekly over a six week period. At the end of 21 days, the animals were euthanized and blood and organs were collected, analyzed, and statistically evaluated. Data obtained from this study demonstrated that supraphysiological levels of androgens given in a sustained manner for long duration to adult male rats resulted in an increased level of IL-6, as well as, major alterations in lipoprotein profiles (total cholesterol, VLDL/LDL, and HDL). Histopathological evaluations of vital (heart, kidney and adrenal tissues) and major reproductive organs rev...Continue Reading

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