PMID: 11913726Mar 27, 2002Paper

The use of animal models in expression pharmacogenomic analyses

The Pharmacogenomics Journal
B E Rothberg

Abstract

Expression pharmacogenomics applies genome/proteome scale differential expression technologies to both in vivo and in vitro models of drug response to identify candidate markers correlative with and predictive of drug toxicity and efficacy. It is anticipated to streamline drug development by triaging towards lead compounds and clinical candidates that maximize efficacy while minimizing safety risks. As the majority of expression pharmacogenomics will be performed on preclinical therapeutic candidates, compatibility with favored preclinical animal model systems will be essential. This review will address expression pharmacogenomics in the context of those animal model systems commonly used for pharmacokinetic, pharmacodynamic and toxicologic analyses. Specific discussions will cover: (A) relative robustness of genomic and proteomic technology platforms used to generate drug response data in critical model systems; (B) animal handling, treatment and other experimental design optimizations; (C) data analysis strategies for extracting and validating candidate pharmacogenomic markers; and (D) overarching limitations in applying expression pharmacogenomics to animal model systems.

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Citations

Feb 25, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Michelle A Penny, Duncan McHale
Dec 12, 2001·European Journal of Heart Failure·F Mehraban, J E Tomlinson
Mar 21, 2002·Expert Review of Molecular Diagnostics·S Katsuma, G Tsujimoto
Sep 23, 2014·The Journal of School Nursing : the Official Publication of the National Association of School Nurses·Lisbet Engh Kraft, Ulla-Britt Eriksson
Aug 7, 2008·PLoS Neglected Tropical Diseases·Aaron R JexRobin B Gasser
Jun 29, 2005·Neurosurgical Review·Mazhar HusainRakesh K Gupta

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