The use of antibiotics in open fractures

The Surgical Clinics of North America
M J Patzakis

Abstract

The use of the term "prophylactic antibiotics" is probably not appropriate because we are in fact treating contaminated wounds. Only broad spectrum antibiotics that can be expected to be effective against coagulase-positive Staphylococcus aureus should be selected for antibiotic therapy in open fractures. We have found cephalothin-cephalexin therapy to be effective in significantly reducing the infection rate. However, the final selection of antibiotic treatment should be determined by the previous experience of organisms isolated and sensitivity studies done from open fracture wounds in each institution. These organisms will vary from hospital to hospital.

Citations

Sep 19, 2006·Surgical Infections·Carl J HauserUNKNOWN Council of the Surgical Infection Society
Nov 26, 2009·The Journal of International Medical Research·Tomaz VelnarV Smrkolj
Feb 1, 1982·Acta Orthopaedica Scandinavica·B R Bergman
Aug 21, 2021·Journal of Orthopaedic Trauma·Henry C Sagi, Michael J Patzakis
Jul 1, 1995·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·A N AcelloN M Pachuda

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