PMID: 9446321Jan 31, 1998Paper

The use of antisense oligonucleotides for modulation of cytokine gene expression

Voprosy medit︠s︡inskoĭ khimii
V A Kozlov, S V Sennikov

Abstract

The review summarizes literature data on the mechanism of action and the use of antisence oligonucleotides for modulation of cytokine gene expression in haemo- and immunopoesis. This new approach for gene-directed modulation of the gene expression allows to analyze both intercellular and intracellular protein interaction. Use of this approach is prospective for both experimental researches in vivo and in vitro and application in therapeutic purposes.

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