The use of atypical antipsychotics in French psychiatric hospitals

Pharmacy World & Science : PWS
Marie Christine BretAnnie Fourier-Réglat


To study the prescribing practices of atypical antipsychotic drugs in French psychiatric hospitals. A 1-day cross-sectional observational survey was performed in seven psychiatric hospitals to study prescribing practices of the four atypical antipsychotics (AAP) marketed in France. These hospitals are members of the PIC network, a pharmacists' working group based in southwestern France. Type and dosages of prescribed atypical antipsychotics, indication and concomitant prescriptions. The study included 1475 adult inpatients' prescriptions with an antipsychotic drug; 647 prescriptions included an AAP with risperidone and olanzapine accounting for about 70% cases. AAP prescriptions concerned psychotic patients in 65% of cases. Patients receiving an AAP in this indication were more likely to be male, were younger, and received higher daily doses than patients treated for other troubles. They were also more likely to receive associated neuroleptic and anticholinergic antiparkinsonian agents. There were 59 prescriptions (9.1%) for bipolar disorders. Clozapine wasn't used in this indication. In 76.3% of cases, mood stabilizers were associated to the AAP prescribed in this indication. This observational survey underlines the significan...Continue Reading


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