The use of Biobrane® for wound coverage in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Burns : Journal of the International Society for Burn Injuries
Alan D RogersRobert Cartotto

Abstract

Published experience describing the use of Biobrane® for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane® in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane® for wound coverage in SJS-TEN. A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Biobrane® application was performed at burn center admission. Values are presented as the median (IQR), or mean±SD where appropriate. We identified 42 eligible subjects with SJS-TEN. Biobrane® was applied in 24 subjects. Biobrane®-treated subjects had an age of 51.4±21.7years, with a %TBSA epidermal detachment of 39.5 (30-46), 63% were female and the admission SCORTEN was 3 (2-4, range 1-5). Biobrane® was applied at burn center (BC) admission in 18/24 subjects (82%), and between post admission days 1-4 in four subjects. Biobrane® was applied to 35 (22-40) % of the TBSA (range 7-90) involving all anatomic areas including the head and neck. There were no complications, infections, ...Continue Reading

Citations

May 1, 2021·Medicina·Arij El Khatib, Marc G Jeschke
May 4, 2021·Frontiers in Bioengineering and Biotechnology·Bretislav LipovýSerhiy Forostyak

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