The use of bone cement for the localized, controlled release of the antibiotics vancomycin, linezolid, or fusidic acid: effect of additives on drug release rates and mechanical strength

Drug Delivery and Translational Research
John K JacksonHelen M Burt

Abstract

Bone cement containing antibiotics is commonly used to treat orthopedic related infections. However, effective treatment (especially of resistant bacteria, methacillin-resistant Staphylococcus aureus (MRSA)) is compromised by very low levels of drug release so that typically less than 10% of loaded drug is released over a 6-week period. The objective of this study was to investigate the effect of incorporation of water soluble excipients (polyethylene glycol, sodium chloride, or dextran) into antibiotic-loaded cement on mechanical strength and drug release properties. Poly(methyl methylacrylate) cement implants containing various amounts of drug (vancomycin, linezolid or fusidic acid (all MRSA active)) and excipients were cast in the form of beads or films and characterized using differential scanning calorimetry. Mechanical strength as assessed by Young's modulus was determined by thermo-mechanical analysis. Drug release was measured by incubation in phosphate buffered saline with analysis by HPLC methods. The inclusion of sodium chloride up to 20% w/w caused only minor reductions in Young's modulus. Vancomycin and linezolid released very slowly from unmodified bone cement beads (less than 3% released by 4 weeks) whereas fusid...Continue Reading

References

May 1, 1977·The Journal of Bone and Joint Surgery. British Volume·R A ElsonD Verettas
Mar 1, 1996·Pharmaceutical Research·C I WinternitzH M Burt
Oct 21, 1999·International Journal of Antimicrobial Agents·B Atkins, T Gottlieb
Nov 24, 1999·International Journal of Pharmaceutics·M L VeyriesB Rouveix
Jul 6, 2000·Drugs·K Kanellakopoulou, E J Giamarellos-Bourboulis
May 17, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensBarry Hafkin
Apr 22, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steve W N UengJui-Hsun Weng
Nov 24, 2004·Clinical Orthopaedics and Related Research·Charalampos G ZalavrasPaul Holtom
Jan 26, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daniëlle NeutHenk J Busscher
Feb 14, 2006·Clinical Orthopaedics and Related Research·Paloma Anguita-AlonsoRobin Patel
Jun 23, 2006·Drugs·Andrej Trampuz, Werner Zimmerli
Jun 29, 2006·Current Opinion in Infectious Diseases·Andrej Trampuz, Andreas F Widmer
Aug 25, 2006·Acta Orthopaedica·Cecilia PerssonMarco Viceconti
Nov 2, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shigui YanHaobo Wu
Mar 3, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C A AboltinsP A Stanley
May 22, 2007·Clinical Orthopaedics and Related Research·Michael VercilloCharalampos G Zalavras
Jun 19, 2007·Diagnostic Microbiology and Infectious Disease·Nalini Rao, Cindy W Hamilton
Feb 20, 2008·International Orthopaedics·Anastasios Lilikakis, Michael P F Sutcliffe
Apr 9, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Konstantinos AnagnostakosStefanie Swoboda
May 22, 2008·La Chirurgia degli organi di movimento·Agnese AndollinaDomenico Tigani
Jun 7, 2008·The Journal of Arthroplasty·Massimiliano BaleaniDomenico Tigani
Aug 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Matthew E Falagas, Konstantinos Z Vardakas
May 1, 2009·Acta Orthopaedica·Konstantinos AnagnostakosJens Kelm
May 15, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S NguyenE Senneville
Jun 30, 2009·Current Opinion in Critical Care·Martin E Stryjewski, G Ralph Corey
Jul 3, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hee-Chang JangKang Won Choe
Jul 29, 2009·Antimicrobial Agents and Chemotherapy·Shveta Rani SinghKimberly A Couch
Sep 22, 2009·The Journal of Infection·Donald C Vinh, Ethan Rubinstein
Oct 6, 2009·Current Drug Targets·R MavigliaM Pennisi

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Citations

Sep 29, 2011·Advanced Drug Delivery Reviews·Yuwei Wang, David W Grainger
Jun 23, 2016·Drug Delivery and Translational Research·Prabhat BhusalDarren Svirskis
May 5, 2016·Journal of Biomedical Materials Research. Part a·Malihe-Sadat Poormasjedi-MeibodAziz Ghahary
Jun 6, 2013·The American Journal of Gastroenterology·Felix W Leung
Oct 10, 2019·Journal of Applied Oral Science : Revista FOB·Luana Dutra de CarvalhoAdriana P Manso
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Lydia M Mensah, Brian J Love

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