The Use of Bone Morphogenetic Protein in Pediatric Cervical Spine Fusion Surgery: Case Reports and Review of the Literature

Global Spine Journal
Robert W Molinari, Christine Molinari

Abstract

Study Design Case report. Objective There is a paucity of literature describing the use of bone graft substitutes to achieve fusion in the pediatric cervical spine. The outcomes and complications involving the off-label use of bone morphogenetic protein (BMP)-2 in the pediatric cervical spine are not clearly defined. The purpose of this article is to report successful fusion without complications in two pediatric patients who had instrumented occipitocervical fusion using low-dose BMP-2. Methods A retrospective review of the medical records was performed, and the patients were followed for 5 years. Two patients under 10 years of age with upper cervical instability were treated with occipitocervical instrumented fusion using rigid occipitocervical fixation techniques along with conventionally available low-dose BMP-2. A Medline and PubMed literature search was conducted using the terms "bone morphogenetic protein," "BMP," "rh-BMP2," "bone graft substitutes," and "pediatric cervical spine." Results Solid occipitocervical fusion was achieved in both pediatric patients. There were no reported perioperative or follow-up complications. At 5-year follow-up, radiographs in both patients showed successful occipital cervical fusion witho...Continue Reading

References

Oct 31, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kiril V MladenovRalf Stuecker
Oct 14, 2011·Acta Orthopaedica·Per Aspenberg
Sep 25, 2012·Journal of Neurosurgery. Spine·Steven W HwangAndrew Jea
Jul 19, 2013·The Journal of Bone and Joint Surgery. American Volume·Amit JainPaul D Sponseller
Jul 24, 2013·Surgical Neurology International·Nancy E Epstein
Aug 22, 2013·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·N PakkasjärviI Helenius
Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Eugene J CarrageeBranko Kopjar
Jan 15, 2014·The Spine Journal : Official Journal of the North American Spine Society·Chadi A Tannoury, Howard S An
Aug 30, 2014·Journal of Neurosurgery. Pediatrics·Marcus D MazurDouglas L Brockmeyer

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Citations

Jul 8, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andrew T HaleLuke D Tomycz
Feb 26, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Zachary J GreyJames J Cray

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