Abstract
To determine the effects of bumetanide in preterm infants with oliguric acute renal failure (OARF). Retrospective data review and multivariate analysis of urine output and serum creatinine, blood urea nitrogen, Na, K, Cl, and Ca levels before, during, and after bumetanide therapy in preterm infants with OARF whose conditions did not respond to furosemide therapy. A total of 35 infants received bumetanide for OARF after an initial trial of furosemide. Their birth weight, gestational age at birth, and postconceptional age at OARF were 811 ± 326 g, 26 ± 2.75 wks, and 29.2 ± 2.7 wks, respectively. Twenty-nine of the 35 infants (83%) responded to bumetanide. Seventeen of the 35 infants subsequently died in the hospital due to multiorgan dysfunction. For the survivors (n = 18) and 11 of 17 of nonsurvivors, urine output increased from 0.6 ± 0.6 mL/kg/hr to 3.0 ± 2.1 mL/kg/hr during bumetanide therapy (p < .0005). Serum creatinine levels increased from 2.13 ± 0.83 mg/dL to 2.3 ± 0.92 mg/dL (p = .04) during bumetanide treatment, whereas blood urea nitrogen levels decreased after bumetanide therapy from 38 ± 19 mg/dL to 31.67 ± 21.6 mg/dL (p = .049). No significant changes were noted in serum sodium, chloride, or calcium concentration. B...Continue Reading
References
Aug 1, 1977·Pediatric Clinics of North America·R Jain
Nov 1, 1977·Archives of Disease in Childhood·O C Ward, L K Lam
Mar 1, 1978·British Journal of Clinical Pharmacology·L E RamsayP Scott
Sep 1, 1978·British Journal of Clinical Pharmacology·C M KessonD H Lawson
Jul 8, 1975·Tijdschrift voor ziekenverpleging·A van der KuyA J Beysens
Jan 1, 1975·Drugs·D L Davies, G M Wilson
Dec 1, 1992·The Journal of Pediatrics·T G WellsG L Kearns
Apr 1, 1992·British Journal of Clinical Pharmacology·M P KnadlerS D Hall
Jan 1, 1991·International Urology and Nephrology·J Prandota
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F B StapletonR S Green
Jan 1, 1988·Developmental Pharmacology and Therapeutics·P C Walker, S Shankaran
Mar 1, 1988·Pediatric Research·B M JohnstonP D Gluckman
Jan 1, 1984·The Journal of Antimicrobial Chemotherapy·G Kahlmeter, J I Dahlager
Mar 1, 1983·Archives of Disease in Childhood·P T RuddD T Hodes
Aug 1, 1982·Pediatric Clinics of North America·S K Anand
Nov 1, 1982·Journal of Clinical Pharmacology·T TurmenJ V Aranda
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S ShankaranL Fleischmann
Oct 1, 1996·Clinical Pharmacology and Therapeutics·J E SullivanJ L Blumer
Oct 7, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S K Eades, M L Christensen
Feb 1, 2000·The American Journal of the Medical Sciences·D C Brater
May 1, 2002·Current Opinion in Pediatrics·Alfred Drukker, Jean-Pierre Guignard
May 1, 2002·Current Opinion in Pediatrics·Sharon Phillips Andreoli
Dec 24, 2004·Current Opinion in Critical Care·Gina-Marie Barletta, Timothy E Bunchman
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J Rybak
Citations
Jun 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Timothy E Bunchman
Dec 5, 2012·Acta Paediatrica·Deirdre U SweetmanEleanor J Molloy
May 8, 2014·Epilepsia·Martin PuskarjovKai Kaila
Feb 21, 2018·Journal of Inherited Metabolic Disease·Kara R VogelK Michael Gibson
Aug 18, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christina F BulkleyJamie L Miller
Sep 1, 2017·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Alexandra Kesler JohnsonAmy J Jnah
Sep 19, 2018·Nature Reviews. Nephrology·Norberto PericoGiuseppe Remuzzi
May 11, 2017·Journal of Renal Injury Prevention·Vishal PandeyRupesh Raina
Jan 23, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jean-Pierre Guignard, Silvia Iacobelli
Feb 18, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle C Starr, Shina Menon
Mar 6, 2021·Kidney Research and Clinical Practice·Sidharth K SethiRupesh Raina
May 22, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tahagod H MohamedJonathan L Slaughter