The use of bumetanide for oliguric acute renal failure in preterm infants

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Milette OliverosRama Bhat

Abstract

To determine the effects of bumetanide in preterm infants with oliguric acute renal failure (OARF). Retrospective data review and multivariate analysis of urine output and serum creatinine, blood urea nitrogen, Na, K, Cl, and Ca levels before, during, and after bumetanide therapy in preterm infants with OARF whose conditions did not respond to furosemide therapy. A total of 35 infants received bumetanide for OARF after an initial trial of furosemide. Their birth weight, gestational age at birth, and postconceptional age at OARF were 811 ± 326 g, 26 ± 2.75 wks, and 29.2 ± 2.7 wks, respectively. Twenty-nine of the 35 infants (83%) responded to bumetanide. Seventeen of the 35 infants subsequently died in the hospital due to multiorgan dysfunction. For the survivors (n = 18) and 11 of 17 of nonsurvivors, urine output increased from 0.6 ± 0.6 mL/kg/hr to 3.0 ± 2.1 mL/kg/hr during bumetanide therapy (p < .0005). Serum creatinine levels increased from 2.13 ± 0.83 mg/dL to 2.3 ± 0.92 mg/dL (p = .04) during bumetanide treatment, whereas blood urea nitrogen levels decreased after bumetanide therapy from 38 ± 19 mg/dL to 31.67 ± 21.6 mg/dL (p = .049). No significant changes were noted in serum sodium, chloride, or calcium concentration. B...Continue Reading

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Citations

Jun 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Timothy E Bunchman
Dec 5, 2012·Acta Paediatrica·Deirdre U SweetmanEleanor J Molloy
Aug 18, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christina F BulkleyJamie L Miller
Sep 1, 2017·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Alexandra Kesler JohnsonAmy J Jnah
Sep 19, 2018·Nature Reviews. Nephrology·Norberto PericoGiuseppe Remuzzi
May 11, 2017·Journal of Renal Injury Prevention·Vishal PandeyRupesh Raina
Jan 23, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jean-Pierre Guignard, Silvia Iacobelli
Feb 18, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michelle C Starr, Shina Menon
Mar 6, 2021·Kidney Research and Clinical Practice·Sidharth K SethiRupesh Raina
May 22, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tahagod H MohamedJonathan L Slaughter

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