PMID: 2492877Jan 1, 1989Paper

The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer

CA: a Cancer Journal for Clinicians
S F SenerJ Sylvester

Abstract

A retrospective analysis of survival results for colorectal cancer patients in Illinois was performed by the Cancer Incidence and End Results Committee of the Illinois Division of the American Cancer Society. Cancer registry data on 1,774 patients from 63 hospitals were used to investigate whether the preoperative level of serum carcinoembryonic antigen (CEA) was a prognostic indicator of survival for cancers diagnosed between 1976 and 1978. A direct relationship was found between the preoperative level of serum CEA and both the thickness and stage of the tumor at initial diagnosis. For Stage B2/3 colorectal cancer, the actuarial survival curves corresponding to normal, elevated, and markedly elevated CEA levels were significantly different (p less than 0.0001). The five-year survival rates for these patients were 61, 50, and 32 percent, respectively. Similar trends for patients with Stage C2/3 cancer were observed (p = 0.0058). The corresponding five-year survival rates were 44, 30, and 26 percent, respectively. Using a statewide cancer registry system, the analysis suggested that the preoperative level of serum CEA was an indicator of survival in patients with colorectal cancer, independent of the stage of disease at diagnosis.

Citations

Mar 5, 2009·International Journal of Colorectal Disease·V Moreno GarcíaE Casado
Oct 29, 2019·American Journal of Respiratory and Critical Care Medicine·Gail G WeinmannUNKNOWN NHLBI Division of Lung Diseases staff
Jun 2, 2015·Expert Review of Molecular Diagnostics·Zhanfang Ma, Na Liu
Dec 14, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Roshan AgarwalaVishal Sharma
Sep 17, 2004·European Journal of Gastroenterology & Hepatology·Jean-Marc PhelipJean Faivre
May 17, 2011·International Journal of Colorectal Disease·Chao-Wen HsuJui-Ho Wang
Mar 12, 2019·The International Journal of Biological Markers·Winesh RamphalPaul D Gobardhan
Aug 21, 2012·Journal of the Chinese Medical Association : JCMA·Chao-Wen HsuJui-Ho Wang
Mar 12, 2019·International Journal of Colorectal Disease·Yiwei HuangQun Wang
Dec 18, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiao-Jing LuoRui-Hua Xu
Sep 7, 2019·Biosensors & Bioelectronics·Elham SameiyanSeyed Mohammad Taghdisi
Jan 19, 2021·Annals of Surgical Treatment and Research·Hyun Ryung KimBo Young Oh
Apr 24, 2007·European Journal of Internal Medicine·Michael J Duffy

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