The use of canines in the detection of human cancers

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Robert T GordonJennifer Zaayer

Abstract

To determine whether canines could be trained to identify patients with cancer by sniffing the urine obtained from a patient with breast or prostate cancer from among samples obtained from healthy volunteers. Dogs of different breeds were trained by their owners to detect the urine sample from a patient with cancer from among 6 other age- and sex-matched healthy volunteers. After the training was completed, using new samples, 2 test runs were used for each patient with breast cancer and three runs for the patients with prostate cancer against the same matched samples. The configuration of the samples was different for each run. A total of 18 and 33 runs were carried out, respectively. For each cohort, specificity and sensitivity were measured. In the breast cancer tests, of 6 dogs, only 2 performed better than chance in specificity and none were more sensitive than chance. For the prostate sample testing, 4 dogs were used. Two performed significantly better than chance in specificity and none in sensitivity. Although this study did not produce the outcomes desired, the literature supports a potential to use canines for human cancer detection. Better management of urine samples and a more stringent training protocol during our s...Continue Reading

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Citations

Jan 7, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William Benda
May 10, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William Benda
Jan 14, 2010·International Journal of Biomedical Imaging·Adam B NoverAri D Brooks
Nov 26, 2010·BMC Cancer·György HorvathGunnar Paulsson
Jul 28, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Gianfranco Cervellin
Feb 22, 2012·Sensors·Alphus D Wilson, Manuela Baietto
Dec 21, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·William Benda
Apr 2, 2014·Prostate Cancer and Prostatic Diseases·A D AsimakopoulosE Finazzi-Agrò
Jul 12, 2014·Annual Review of Analytical Chemistry·Anton AmannTerence Risby
Sep 25, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Gianluigi TavernaGiorgio Guazzoni
Oct 26, 2010·European Urology·Jean-Nicolas CornuOlivier Cussenot
Jun 15, 2010·Behavioural Brain Research·Glaucie Jussilane AlvesJoão Palermo-Neto
Sep 30, 2014·The Journal of Urology·Gianluigi TavernaPierpaolo Graziotti
Mar 4, 2014·The Journal of Urology·Antti RoineNiku K J Oksala
Apr 6, 2017·Journal of Cellular and Molecular Medicine·Márcia MonteiroPaula Guedes de Pinho
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Feb 11, 2015·Journal of Breath Research·Kristin SchallschmidtIrene Nehls
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Mar 30, 2018·Frontiers in Veterinary Science·Carola Fischer-TenhagenRoland Becker
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy GottwaldWilliam Schneider
Mar 30, 2019·Scientific Reports·Amélie CatalaJennifer Cattet
Dec 4, 2020·Journal of Breath Research·Srikar S MuppidiCharles Moore
Feb 3, 2021·Animals : an Open Access Journal From MDPI·Mallory T DeChantNathaniel J Hall

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