The use of Centiloids for applying [11 C]PiB classification cutoffs across region-of-interest delineation methods

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Dana L TudorascuAnn D Cohen

Abstract

Centiloid standardization was developed to establish a quantitative outcome measure of amyloid burden that could accommodate the integration of different amyloid positron emission tomography radiotracers or different methods of quantifying the same tracer. The goal of this study was to examine the use of Centiloids for establishing amyloid classification cutoffs for differing region-of-interest (ROI) delineation schemes. Using ROIs from hand-drawn delineation in native space as the gold standard, we compared standard uptake value ratios obtained from the 6 hand-drawn ROIs that determine amyloid-positivity classification with standard uptake value ratio obtained from 3 different automated techniques (FreeSurfer, Statistical Parametric Mapping, and superimposed hand-drawn ROIs in Pittsburgh Compound B template space). We tested between-methods reliability using repeated measures models and intraclass correlation coefficients. We found high reliability between the hand-drawn standard method and other methods for almost all the regions considered. However, small differences in standard uptake value ratio were found to lead to unreliable classifications when the hand-drawn native space-derived cutoffs were used across other ROI deli...Continue Reading

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Citations

Dec 14, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Soo Hyun ChoSang Won Seo
Oct 1, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sigan L HartleyBradley T Christian
May 22, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Matthew D ZammitBradley T Christian
Mar 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christopher G Schwarz
Jan 2, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victor L VillemagneAnn D Cohen

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Software Mentioned

PickAtlas
SPM12
ROI Tool
ITK
AIR
PMOD
SAS
SNAP
SPM
FreeSurfer PickAtlas

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